Detection And Significance Of CD55～+ And CD59～+ Cell In The Erythrocyte And Body Fluid Immunity Sign With Acute Leukenia Patients

Objective: To discuss the expression and their significance of red blood cell surface CD55⁺, CD59⁺ molecule with acute leukemia (AL) patient .Methods: The object of study is acute leukemia and healthy crowd. To adopt the immune fluorescence stream style cell instrument, detecting 42 examples AL patients and 42 examples to contrast red blood cell surface CD55⁺, CD59⁺ and CD55⁺/CD59⁺ molecule quantity regularly. Do the parallel T of two equal sample numbers check out. To adopt full-automatic proteinum analytic instrument, detecting 42 examples AL patients and 42 examples contrast the immune person body fluid relevance index regularly, include complement C3_, C₄,and immunoglobulin IgG, IgA, IgM molecule quantity, in red blood cell of patient, CD55⁺, CD59⁺and CD55⁺/CD59⁺ molecule and immune index of body fluid do relevance analysis. Bone marrow is hit by percentages of primitive cell, the AL patients are divided into two groups who have relieved group and not have relieved , according to the chemotherapy front and back, the patient's red blood cell surface CD55⁺, CD59⁺ and CD55⁺/ CD59⁺molecule detected consequence carry out parallel analysis on 2 set. Do the parallel T of two equal sample book numbers check out. Results: Red blood cell surface CD55⁺ ,CD59⁺ and CD55⁺/ CD59⁺ molecule quantity comes down in AL patients, the difference has statistics meaning (p<0.05). Red blood cell surface CD55⁺ molecular quantity is positive correlativity with immunoglobulin IgA,IgG molecule quantity, (p<0.05). and is negative correlativity with complement C3 (p<0.05). Red blood cell surface CD59⁺ molecule quantity is negative correlativity with complement C₃, C₄ (p<0.05). Red blood cell surface CD55⁺/ CD59⁺ molecule quantity is negative correlativity with complement C₃ (p<0.05) and is positive correlativity with immunoglobulin IgA,IgG,IgM molecule quantity , Red blood cell surface CD55⁺ and CD55⁺/CD59⁺molecule quantity is obviously come down in AL patient who have not relieved group than the relieved group, the difference has statistics meaning (p<0.05). Conclusions: The natural immune function of erythrocyte with AL patient comes down; The red blood cell surface CD55, CD59 molecule participate in body fluid immunoreaction regulating and controlling; The quantity of red blood cell surface CD55⁺ and CD55⁺/ CD59⁺ molecular is obviously comes down in which have not relievied group in AL patient. In the process studying treating pointing out that, in the acute leukemia originally, natural sharpening erythrocyte immunity significance diagnosing .Whether the quantity of red blood cell surface CD55⁺ and CD55⁺/ CD59⁺ molecular can be one of immune state of patient and the prognosis index judging AL, wait for a further exploration and study.