Expression Of CD55, CD59in The Chronic Rhinosinusitis And Its Significance

Background: Chronic rhino-sinusitis, one of common diseases in otorhinolaryngology,is chronic inflammation of nasal mucosa. Complement is a kind of protein withbiological effect involved in the reactions of inflammation and immunization, whosefunction in the etiology of chronic rhino-sinusitis, recently, has been the hotter topic.Complement regulatory proteins (CRP), expressed in different histocytes includinghematocytes, vascular endothelial cells and epithelial cells, play a major role in thecomplement regulation by inhibiting damage autologous tissues due to complementactivation. Interactions among CRP and different parts of complement system withspecial way can prevent the damage of autologous tissues of hosts keeping meticulousbalance of complements between activation and inhibition. Currently, CD55and CD59are membrane-bound CRPs studied mostly in immunization of respiratory mucosa.Some studies have reported that high concentrations of C3a and C5a are found in thesecretions of nasal mucosa from patients suffering nasal polyps, which indicates localactivation of complements also occurs in the nasal mucosa from patients suffering nasalpolyps and it is involved in the etiology of nasal polyps. However, the expressions ofCD55and CD59in patients of chronic rhino-sinusitis have not been reported yet. Thepresent study aims to explore the correlation between these two CRPs and etiology ofchronic rhino-sinusitis observing the expressions of CD55and CD59in the tissues ofchronic rhino-sinusitis. Methods: A total of60patients of chronic rhino-sinusitisreceiving endoscopic sinus operations were enrolled from July,2011to July,2012. Allpatients, whose mucosa of maxillary sinus orifices were removed, were divided intosingle group with inflammation and combined group with nasal polyps. Another30patients receiving operations of nasal septal reconstruction were set as the control,samples from which were mucosa of ostiomeatal complex of patients receiving operations of nasal septal reconstruction. The expression of CD55and CD59in thenasal mucosa were treated with immunohistochemical methods. Results：①Comparedwith the control group,the expression of CD55,CD59in the experimental gronp weredescended significantly（P<0.05，P<0.01）.②Compared with the patients without nasalpolyps,the expression of CD55,CD59in the patients with nasal polyps were descended（P<0.05）.Conclusion：The down-regulation of complement regulatory proteins mightinvolve in the pathogenesis of chronic rhinosinusitis.The possible mechanismsassociated with the activation of complement.