The Preliminary Study On Role And Possible Mechanisms Of CXCR4 In The Metastasis Of Renal Cell Carcinoma

Metastases are main reasons for poor prognosis of advanced renal cell carcinoma. It has been reported that tumor cell migration and metastasis share many similarities to leukocyte trafficking, which is critically regulated by chemokines and their receptors. The expression of CXCR4 in renal cell carcinoma, metastasis and uninvolved normal tissue were measured by immunohistochemistry. subcellular localization of CXCR4 when A-498 cells treated with various concentrations of SDF-1β; Matrigel Invasion Chambers are used to study invasion of A-498 cell and assess their invasive property in vitro.The data in this study suggest that CXCR4 expression is correlated with in renal cell carcinoma,and CXCR4 is most likely a new molecular marker for diagnosis of renal carcinoma progression. Testing the CXCR4 expression level in renal cell carcinoma could be helpful in determining RCC metastasis. Internalization of CXCR4 may activate important signaling pathways, which would impact the ability of the tumors to survive. Reduction in membrane staining of CXCR4 in metastases may be associated with the progression of renal cell cancer metastasis.