The Expression Of Caveolin-1 And Paxillin In Gastric Adenocarcinoma And Preneoplastic Changes

Objective: To investigate the expression of caveolin-1 and paxillin in gastric adenocarcinoma (GAC), preneoplastic changes and chronic superficial gastritis (CSG) tissues, and their possible roles in the carcinogenesis and metastasis of GAC. Methods: The expression of caveolin-1 and paxillin in GAC (59 cases), CSG (30 cases) and preneoplastic changes (80 cases), including chronic atrophic gastritis (CAG, 30 cases), intestinal metaplasia (IM, 30 cases), and dysplasia (Dys, 20 cases) tissues were detected by S-P immunohistochemical techniques .Results:1. The staining of caveolin-1 and paxillin in CAG, IM, Dys and GAC tissues was stronger than that of CSG tissues, and the strongest positive staining was found in GAC tissues (P<0.05). No significant difference was found between the staining of caveolin-1 and paxillin in IM and Dys tissues (P>0.05). The staining of caveolin-1 and paxillin was significant positively correlated to gastric mucosal lesion degrees (rs=0.792, P=0.000 and rs=0.779, P=0.000, respectively ).2.The staining of caveolin-1 and paxillin in the advanced GAG tissues was higher than that in the early stage (P<0.05).3.In the GAC, the staining of caveolin-1 and paxillin in tissues with lymph metastasis was higher than that in without (P<0.05).4.No significant difference was found among the staining of caveolin-1 in well-, moderately- and poorly-differentiated GAC tissues (P>0.05). The staining of paxillin in well-differentiated GAC tissues was lower than that in moderately- and poorly-differentiated GAC tissues (P<0.05), while no significant difference was found between the expression of moderately- and poorly-differentiated GAC tissues (P>0.05).Conclusion: The up-regulation of caveolin-1 and paxillin expression may play an important role in the carcinogenesis and metastasis of gastric adenocarcinoma. The influence of them may emerge in the early stage of carcinogenesis of GAC and continue to the advanced stage, which implied the potential roles of caveolin-1 and paxillin for the prediction of lymph netastasis. The expression tendence of caveolin-1 showed highly coincidence to that of paxillin in the preneoplastic changes and GAC tissues, which may imply a close relationship between them in the carcinogenesis.