The Clinical Application Of Contrast-enhanced Ultrasound In Diagnosis And Treatment Of Focal Liver Lesions

Purpose: To observe the characteristics of focal liver lesions by using contrast-enhanced ultrasound, to investigate the clinical value of real time gray-scale contrast-enhanced ultrasound for diagnosis and treatment of focal liver lesions.Methods: Sixty-seven patients were prospectively evaluated with contrast-tuned imaging using the microbubble contrast agent SonoVue under a low mechanical index. The results of contrast-enhanced ultrasound were compared with that of conventional ultrasound,contrast-enhanced CT and pathology.Results: The pathology result is Twenty-eight malignant lesions (hepatocellular carcinoma, n=19; metastatic liver cancer, n=9),32 benign lesions (hemangioma, n=11; inflammatory lesions, n=9; focal nodular hyperplasia, n=4; regenerative, n=6; adenoma, n=1; cyst, n=1) and 7 hepatocellular carcinoma cases after nonoperative were diagnosed in the study.1. The enhancement duration time and extinct time of benign group was longer than maglinant group (P<0.05).2. For differentiation of malignant and benign focal liver lesions, the sensitivity, speciality of contrast-enhanced Ultrasound,contrast-enhanced CT and conventional ultrasound is 96.4%, 87.5%; 92.8%, 90.6%; 46.4%, 43.8%, respectively. The accuracy rate for diagnosing focal liver lesions of CEUS,contrast-enhanced CT and conventional ultrasound was 93.3%, 91.7 %, 45.0%, respectively.3. In the 7 hepatocellular carcinoma cases after nonoperative, there was two cases show contrast microbubble enter the lesions in the artery phase and 5cases show no contrast microbubble enter the lesins from begin to the end.Conclusion: Contrast-enhanced Ultrasound can significantly improve sensitivity, speciality and the accuracy rate for diagnosing focal hepatic lesions to compare with conventional ultrasound. The accuracy rate have no significant to compare with contrast-enhanced CT. So it is very important in clinical application.