Diagnosis Of Focal Lesions Of Pancreas In Contrast-enhanced Ultrasound And Comparison With Contrast-Enhanced CT

ObjectiveTo observe the enhancement patterns of Focal lesions of pancreas and evaluate the role of Contrast-enhanced Untrasound in diagnoising pancreatic disease compared with Enhanced CT.MethodsTwenty-one patients suspected with FLPs were underwent CEUS examination with GE Logiq 9 color sonographic system,which with 4C probe, frequency:2-4MHz, low mechanic index:0.07-0.10,these patients were underwent operation from July 2008 to May 2009.Patients were fast about eight hours before examination and drunk water about 800 millilitre just before examination.then we gained primary diagnosis through observing the size,margin,echowith conventional ultrasound and vascular with color Doppler system.The pancreas was scanned with a conventional sonogram to select an appropriate section,using contrast enhanced sonograme mode,Sonovue was injected as a bonus of 2.4ml through the antecubital vein,the entire scanning process was recorded for 5 min.The enhancement and patterns were analyzed to obtain the TIC curve,record the curve parameters:Start-time,Peak-time, Enhance-time and peak intensity was recorded.ResultIn Twenty-one cases,ten cases were benign,eleven cases were malignant. most of the pancreatic carcinomas showed inhomogeneous hypoenhancement in Arterial-time, most of the benigns showed homogeneous tautoenhancement or altusenhancement. Enhance-time of malignant lesions was shorter than that of benigns and normal pancreatic tissue.If using hypoenhancement as a diagnosis indicator, the sensitivity, specificity, positive predictive value, negative predictive value and accuraty were 72.7%,80.0%,80.0%,72.7%and 76.2% for pancreatic carcinomas. Correct diagnosis rate of focal lesions of pancreas in CEUS and CECT was 81.0%,85.7%.ConclusionsContrast-enhanced Ultrosound reflect microcirculation objectively and provide more information in the diagnosis of focal lesions of pancreas than conventional ultrasound, FLPs have different appearance in Contrast-enhanced Ultrosound which provide information in differential diagnosis. Contrast-enhanced Ultrosound have the same value in the diagnosis as enhanced CT and make better perspective in Clinical application.