Diagnostic Value Of Real-time Contrast-enhanced Ultrasound And Contrast-enhanced Computed Tomography,Contrast-enhanced MRI For Focal Liver Lesions: A Meta-analysis

ObjectiveTo compare the diagnostic value of real-time contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography(CECT) contrast-enhanced MRI(CEMRI) for focal liver lesions.MethodsPubMed, Cochrane library, CBM (1979-2009) and CNKI (1979-2009) database were searched for English and Chinese language articles related to real-time CEUS and CECT, CEMRI diagnosis for focal liver lesions. Articles were evaluated. Data were pooled by Metadisc software.ResultsTotally 49 studies were analysed. All of them were comparative studies,23 of those studies are prospective and 15 of them are retrospective,11 of them are without description. A total of 5281 specimens,6110 focus of infection were included in real-time CEUS group and the pooled sensitivity, specificity and the AUC of weighted summary receiver operating characteristic (SROC) curve were 0.89,0.90 and 0.9656, respectively.1755 specimens,1914 focus of infection were included in CECT group and the above numbers were 0.89,0.84 and 0.9528.633 specimens,790 focus of infection were included in CEMRI group and the above numbers were 0.79,0.84 and 0.8956.ConclusionThe accuracy of real-time CEUS and CECT, CEMRI has no difference in diagnosing focal liver lesions.