The Study Of CXCR₅ Expression In Peripheral Blood CD₄～+ T Cells Of Myasthenia Gravis Patients

Objective:To investigate the role of CXCR₅ in the disease of MG.Methods:We studied the frequency of CXCR₅-positive lymphocytes in the peripheral blood of 36 MG patients and 23 healthy donors.MG group was subdivided into subgroups according to their clinical absolute scores.Results:Before therapy,the MG patients showed a significantly higher frequency of CXCR₅⁺ CD₄⁺ T cells in the peripheral blood compared with the control group(t=5.33,P＜0.01),while the CXCR₅⁺ CD₄⁺ T cell frequency of MG patients with Osserman typeâ…¡was significantly higher than that of those with Osserman typeâ… and the CXCR₅⁺ CD₄⁺ T cell frequency of MG patients with Osserman typeâ…£was significantly higher than that of those with Osserman typeâ…¡(P＜0.01).The CXCR₅⁺ CD₄⁺ T cell frequency of MG patients with abnormal thymus was significantly higher than that of those with normal one(P＜0.05)A significant correlation was observed between the percentage of CXCR5⁺ CD4⁺ T cells and the disease severity(r_s=0.764,P＜0.01). No significant difference in the percentages of CXCR₅⁺ CD₄⁺ T cells was observed between the patients with AchRab and those without AchRab(P＞0.05), and was observed between the patients with PsmRab and those without PsmRab (P＞0.05)Conclutions:(1)Our results suggest that CXCR₅ play an important role in the disease activity of MG and Hyperexpression of CXCR₅ is correlated with the clinical progression of MG.(2)There was some differences between the pathologies of MG with normal thymus and that of MG with abnormal one. (3)Contrlling the expression of CXCR₅ may interrupt the immune process of MG patients.