Expression Of Fragile Histidine Triad (FHIT) And Mut S Homolog 2 (MSH2) Protein And Their Significance In Cervical Carcinoma And CIN In Xinjiang Women

Objective:To investigate significance and correlation of expression of FHIT and MSH2 protein in cervical carcinoma in Xinjiang women.Methods:The expression of FHIT and MSH2 was examined by immunohistochemical SP method in 35 cervical carcinomas,57 CIN and 20 normal cervix tissues.Results:The positive expression of FHIT was 90.0%,73.7%,22.9%in cervical carcinoma,CIN,and normal cervix tissues respectively,and the difference was statistically significant;CINⅠ-Ⅱ(84.4%)＞CINⅢ(60.0%),high differentiation(33.3%)＞middle-low differentiation(15.0%)and there was no obvious difference.The expression of FHIT was different between Han(42.9%)and Uighur(10.5%)nationality(P＜0.05).(2)The positive expression of MSH2 was 65.0%,63.2%,and 71.4%in above tissues respectively,and the difference was not statistically significant;CINⅢ(76.0%)＞CINⅠ-Ⅱ(53.1%),middle-low differentiation(75.0%)＞high differentiation(66.7%).There was no obvious difference(P＞0.05).The expression of MSH2 in cervical carcinoma and CIN was not different between Han and Uighur nationality(P＞0.05).(3)The expression rates of MSH2 in positive and negative FHIT subjects were 75.0%and 70.4%respectively.The consistent expression rate of FHIT and MSH2 was 40%.There was no correlation between the expression of FHIT and MSH2 in cervical carcinoma(r=0.043,P＞0.05).Conclusion: (1)The descending expression of FHIT plays an important role in development of cervical carcinoma,and is more obvious in Uighur nationality.(2)It may be used as a marker to serve mass screening of CIN-high risk subjects and diagnostic inductor for early carcinoma.(3)The expression of MSH2 increases from CIN to cervical carcinoma.(4) There may be no correlation between the expression of FHIT and MSH2 in cervical carcinoma.