Effect Of Epristeride On Decreasing Intraoperative Bleeding During Transurethral Resection Of Prostate

Objectives: To evaluate the effect of pretreatment with epristeride on decreasing intraoperative bleeding during TURP , and to study its mechanism.Methods: 55 patients with benign prostatic hyperplasia undergoing TURP were divided into two groups: 25 patients were pretreated with epristeride 5mg×2 daily for 7 to 11 days before TURP and 30 patients without pretreatment. The operation time, the weight of resected prostatic tissue, and the volume of irrigating fluid were recorded. Bleeding quantity, bleeding index and bleeding intension were calculated. Microvessel density(MVD), vascular endothelial growth factors(VEGF) and nitric oxide synthase type III(eNOS) expression were measured by immunohistochemistry SP method in prostatic tissue.Results: In epristeride group and control group, the mean bleeding quantity was (179.51±78.29)ml and (237.95±124.38)ml (P<0.05); the mean bleeding index was (7.68±3.94)ml/g and (9.73±3.42)ml/g (P<0.05); the mean bleeding intension was (2.43±1.03)ml/min and (3.30±1.50)ml/min (P<0.05); the mean value of MVD was 18.80±5.68 and 23.70±4.91 (P<0.05); the mean rank of VEGF was 23.48 and 31.77 (P<0.05) ; and the mean rank of eNOS was 22.36 and 31.14(P<0.05); respectively.Conclusions: Pretreatment with epristeride is effective on decreasing intraoperative bleeding during TURP. The preliminary results suggest that angiogenesis in the prostatic tissue is suppressed.