Graves Disease Patients Function Of Blood Vessel Endothelium Before And After Treatment And Observation Comparison

Diffuse toxic goiter which is the frequent type of hyperthyroidism is one of organ-specific and autoimmunity diseases with much secretion of thyroid hormone. Except leading the change of organism itself, it destroys vascular endothelial cell directly and indirectly, affect the function of blood vessel endothelium and change the architecture and function of vessel. A lot of prospective clinical trial proved that the change of function of blood vessel endothelium can lead disease of blood vessel, which induce cordis and cerebral vessel disease. Function of blood vessel endothelium damaged is the important risk factor of cordis and cerebral vessel disease which disorders the fuction of secrete concluding the composition and releasing of ET and NO that not only aggravate Graves but also many diseases. In earlier period, discovering the change of function of blood vessel endothelium by Graves precisely and observing it during treating, at same time promptly and rationally intervening it not only can treat disease itself but also prevent its secondary affections. Our research view from the angle of early diagnosis of disease. We can observe the dynamic changes in treating process, appraisal it objectively and precisely and intervene research aspects timely and effectively.Echo-tracking technique can judge the function of blood vessel endothelium by ultrasonic testing of arterial blood.Through the anterior and posterior wall of the vessel to conduct real-time trajectory of the track and monitor, automatic calculation artery endothelial function changes observed achieve artery endothelial function testing.The research results show that the E-Tracking technology, and easy-to-operate, non-invasive, high sensitivity, repeatability and good benefits, morphological changes in the blood vessels prior to the detection of early artery endothelial function in the occurrence of damage.The use of Japan ALOKA SSD-5500 Color ultrasonic machine, the 37 cases in patients with Graves disease before treatment, after treatment for three months and six months after the application of E-Tracking technology artery endothelial function changes observed : Eρcoefficient of elasticity, rigidity of theβand compliance AC, observe and analyze the changes.The results showed: 1, 4 between the two-dimensional ultrasound observation, endometrial vascular smooth, atherosclerotic plaque formation in the membrane thickening, measured no significant difference. 2, Graves disease before treatment group and the normal control group compared to the coefficient of elasticity Eρsignificantly higher than the normal control group (P<0.01), there are significant differences in stiffnessβhigher than the normal control group, the control group decreased compliance AC , and there are differences (P<0.05). The changes mentioned above, the existence of patients with Graves disease vascular endothelial dysfunction, and vascular morphology occurred before the change, changes in the coefficient of elasticity EρObviously, it is because of its greater impact on the pulse pressure, when Graves disease, increased pulse pressure . 3, Graves disease before treatment group and Graves disease after treatment between the three-month comparison, the coefficient of elasticity Eρ, stiffnessβ, compliance between AC no significant difference. Despite the anti-thyroid drug therapy in patients with stable condition, the symptoms disappeared, T3 and T4 levels in the normal range, but in the short term there is no obvious vascular endothelial function changes, the danger of which still exist. 4, and 6 months after treatment group and the treatment group, the coefficient of elasticity EρGraves disease was significantly lower than before treatment (P<0.01), there are significant differences in stiffnessβbelow Graves disease before treatment group, higher than AC compliance Graves disease before treatment group, numerical change, but there is no significant difference. 6 months after treatment group and three months after the treatment group compared coefficient of elasticity EρGraves disease was significantly lower than before treatment(P<0.01),there are significant differences;stiffnessβlower than the stiffness of Graves disease before treatment group, higher than the compliance AC Graves disease before treatment group, numerical change, but there is no significant difference. Application of anti-thyroid medication after a period of time, to reduce the level of thyroid hormone in the normal range, vascular endothelial function gradually recovered. 5, and 6 months after treatment group and the normal control group, the coefficient of elasticity Eρhigher than the normal control group, stiffnessβhigher than the control group, Compliance AC lower than the control group, there are differences (P <0.05). This shows that the vascular endothelial function after treatment, although improved, but there are still vascular endothelial dysfunction. The above results we can conclude: Graves disease due to increase in thyroid hormone secretion caused by high metabolism, high pulse pressure and hemodynamic changes, such as increasing, as well as increased levels of thyroid hormone caused by the release of ET and NO synthesis increased to the vascular endothelial injury caused vascular endothelial dysfunction. Graves disease in patients with early two-dimensional ultrasound, vascular no obvious morphological changes. Change its vascular endothelial function in early vascular morphological changes. Graves disease after treatment of vascular endothelial function in the short term there is no obvious improvement, after a period of sustained treatment in a stable condition without repeatedly, vascular endothelial function gradually improved. But compared with the normal group, vascular endothelial dysfunction still exist.Graves disease, increased levels of thyroid hormone, thyroid hormone itself and caused by a series of increased change can cause vascular endothelial damage, which in previous studies has been confirmed. Through our research vessel tracking echo observed in patients with Graves vascular endothelial dysfunction, in patients with Graves confirmed the existence of vascular endothelial dysfunction, and after treatment in patients with Graves dynamic observation of vascular endothelial function in the different periods after treatment of vascular endothelial function evaluation of clinical intervention can provide an evaluation of the objectives and methodology. Test results from all the machines are automatic tracking that automatically show the systolic and diastolic blood vessel diameter changes, automatic calculation of the coefficient of elasticity Eρ, stiffnessβand compliance AC, eliminating the previous measurements of vascular diameter and Eρ,βand the AC tedious and complicated process, reducing the human error factor, the results of the tests more accurate. For the clinical treatment programme choices, and the resulting in the prevention of diseases is of important significance.We have used E-Tracking Graves observed in patients with vascular endothelial function and the change in the treatment for clinical treatment of Graves disease programme of choice, as well as its vascular endothelial function after injury, caused by the disease is important in the prevention of significance. E-Tracking technology for noninvasive vascular testing technology, is a simple, non-invasive and highly sensitive, reproducible, and other advantages in the early detection of vascular endothelial function, and be able to observe the dynamic changes in the share of important value.