| Hyperthyroidism is a kind of familiar endocrine disease, Because a certain reason, thyroid gland hyperfunction, it excreted luxus thyroid hormone to enter blood circulation, thyroid hormone of the high level entered whole body with the blood circulation, leaded each system of function confused. Domestic and international many scholars confirmed from many experiments: 1,The high level of thyroid hormone can directly damage vascular endothelial cell; 2,Thyroid hormone of content steped up to lead vascular endothelial cell to derive NO, But NO had cytotoxicity, it can cause glyceraldehyde-3- phosphate dehydrogenase ribosylation, blocked glycolytic cycle to block ATP create, binded mitochondrial respiratory chain or mitochondrial synthetase of contain iron part, hold mitochondrial synthetase of electron transport, hold Aconitase,RNA reducase and DNA rate-limiting enzyme's activity, hold cells of biological oxidation to produce energy, hold vascular endothelial cell to hyperplasia; 3,Thyroid hormone of content steped up to lead vascular endothelial cell to derive ET, ET can cause coronary artery and environ artery to contract, leaded patients heart rate to raise, systolic pressure to raise,pulse pressure to increase breadth, cardiac output to increase,blood current to accelerate. The high speed fluxion of blood can violent impact blood vessel of inside wall, cause vascular endothelial cell to be hurt and transparence to increase. Hyperthyroidism patients of vascular endothelial cell to be hurt must affect hyperthyroidism patients of blood vessel endothelium function. But, hyperthyroidism patients of blood vessel endothelium function were hurt that were hyperthyroidism patients cardiovascular system complication earlier period of appearance. moreover, earlier period,no insult,can be repeated,can be quantity and simple evaluation hyperthyroidism patients's blood vessel endothelium function, in order to clinical fromed and treatmented hyperthyroidism patients cardiovascular system complication provide dependable objective basis was the main purpose of this research.This research selected from February, 2006 to December 2006 our hospital clinical diagnosised hyperthyroidism Var. mitis of patients 57cases to hyperthyroidism group;selected ages and sex as same as hyperthyroidism group, and carry various checks to removethyroid disease,hypertension,hyperlipemia,diabetes mellitus and serious heart,liver,kidney etc, health examination 71 cases normal checked group. E-Tracking technology was performed to follow the movement tracks of the common carotid arterial wall, and the following parameters were assessed respectively: internal systolic diameter (Ds), internal diastolic diameter (Dd), elasticicity modulus (Ep), stiffness parameter (β), and arterial compliance (AC). Results show: Ds: hyperthyroidism group were higher than normal control group (P<0.05); Dd: hyperthyroidism group were lower than normal control group (P<0.05); AC: hyperthyroidism group were lower than normal control group (P<0.05); Ep: hyperthyroidism group were higher than normal control group (P<0.01);β: hyperthyroidism group were higher than normal control group (P<0.05). E-Tracking technology can be used to early reflect the blood vessel endothelium function changes of hyperthyroidism patients, and it is a convenient method.This research result show: hyperthyroidism group of blood vessel inside diameter had light degree change, because Thyroid hormone of content steped up to lead vascular endothelial cell to derive large NO and ET, ET and NO can use vascular smooth muscle cell, leaded blood vessel inside diameter to change, and because of this research selected Var. mitis of hyperthyroidism patients,patients with disease of time was short,pathogenetic condition was light, HR<100 order/minute, T4<258nmol/L, thyroid uptake four hours >35%, ttwenty-four hours>54%, therewhith blood vessel inside diameter of difference had very light change, so hyperthyroidism group and normal control group had difference, P<0.05. Hyperthyroidism group of Ep were higher than normal control group, architecture consumed oxygen were raise leaded opposite hypoxia, leaded small vessels to relax, peripheral vascular resistance to step down, diastolic pressure were normal or lower, pulse pressure of difference were raise.Ep were artery of elasticity, Ep=(Ps-Pd)/[(Ds–Dd)/Dd], from the formula can see, pulse pressure of difference were bigger factor of effcctive Ep, so Ep were higher than normal control group, had obvious difference, P<0.01. Hyperthyroidism groupβwere higher than normal control group, because ofβwas sclerosis degree of artery,β=In (Ps/Pd)/ [(Ds-Dd)/Dd], from the formula can see, the parametertake used systolic pressure and diastolic pressure of ratio of natural logarithms, though pulse pressure difference ofβwere lower than Ep factor of effcctive, soβwere higher than normal control group, had difference, P<0.05. Hyperthyroidism group AC were lower than normal control group, because of AC was complaisance of artery, AC=π(Ds×Ds-Dd×Dd)/4(Ps-Pd), When the artery of endothelium were hurt, the number were lower, though, AC were lower than normal control group.This research result one hand, from angle of macro view objectify,quantity of charge prove thyroid hormone increase to lead to damage vascular endothelial function; on the other hand clinic demand were satisfied that diagnosis of earlier period hyperthyroidism patients of contaminate of cardiovascular system; and affiremed the E-Track- ing technique examined blood vessel endothelium function of superi- ority. |
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