| Mycoplasma genitalium (Mg) was first identified in the early 1980s among men with nongonococcal urethritis (NGU). Its unique biological characteristics and the relation with nongonococcal urethritis,chronic prostatitis,cervicitis,pelvic inflammatory disease and HIV infections have been focused by scholars. Mucopurulent cervicitis (MPC) is a frequent condition of young women attending a sexually transmitted diseases (STD) clinic. Although Neisseria gonorrhoeae (Ng) and/or Chlamydia trachomatis (Ct) are/is recovered from approximately a third to a half of women with it, the etiologic agent of nongonococcal nonchlamydial cervicitis (NGNCC) is often unidentified. And treatment is depended on experience, so the treatment is not very effectective. Detection of the pathogens may result into specific therapeutic measures, with varying degrees of success.In recent years, several studies have shown that Mg is strongly associated with MPC, but few general studies about Mg and NGNCC in particular. The aim of this study was to obtain information on Mg infection with NGNCC concerning prevalence, association to clinical manifestations, the situation of epidemiology and risk factors.We detected Mg,Ct,Ng,Ureaplasma urealyticum (Uu),Mycoplasma hominis (Mh) by culture and PCR methods;Trichomonas vaginalis (Tv) by wet-mount microscopy. Cervical secretions were obtained from 3 different female populations: 158 NGNCC patients, 98 non-NGNCC patients and 94 healthy volunteers. At the same time, a structured questionnaire was filled by the participants for information about age, marital status, the culture level and the infection sources, age at first intercourse, cervical status, number of sex partmers in the past two years, averange frequency of sexual intercourse, condom using, history of cervicitis or other STDs history in the past two years, and sex partner's STDs history. The Mg positive patients without other pathogens were detected Mg again after treatment.Results: (1) We detected Mg in 16(10.13%) of 158 NGNCC patients. Among the 16 positive cases, 4 had other pathogens, of which Uu was the most common. Respectively, the positive rates Mg in non-NGNCC patients and healthy volunteers were 3.06%(3/98) and 0.00%. Significant difference was found each two groups (P<0.05) except non-NGNCC patients and healthy volunteers (P>0.05). (2) Mucopurulent secretion was the most common clinical feature of 16 Mg infection of NGNCC. 11 cases (68.75%) had persistent or recurrent cervicitis. (3) The epidemiological survey and analysis of Mg positive with NGNCC cases:①26~35 year-old people were the most common;②less likely to have more than a high school education, service and the jobless were the most in the professional;③the city region was the major in the region distributing;④the married women had the higher percentage;⑤62.50%(10/16) had experience of sexual intercourse with more than 2 sexual partners. (4) Minocycline can eradicated Mg from 10 cases of NGNCC with Mg infection. 9 cases'signs and symptoms of cervicitis disappeared. (5) The relevant factors of infection with Mg were more than 2 life-time sexual parners (OR=5.542, 95%CI 1.945~15.787), the average frequency of sexual intercourse(OR=5.382, 95%CI 1.881~15.398) and had history of cervicitis (OR=5.824, 95%CI 1.923~17.643).Our conclusion: (1) Mg is prevalent in the cervix of women with NGNCC, it's strongly associated with NGNCC. (2) We should pay more attention to the high risk population. (3) Minocycline can eradicated Mg infection, and signs and symptoms of cervicitis can be improved. (4) Epidemics and transmitting of NGNCC were associated with many risk factors. This study provides the experimental evidence for the pathogen, diagnosis and treatment of the NGNCC, and is helpful in the prevention of it. |
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