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Effects Of Viscum Coloratum On Experimental Arrhythmia

Posted on:2009-03-10Degree:MasterType:Thesis
Country:ChinaCandidate:J J MaFull Text:PDF
GTID:2144360242481531Subject:Pharmacology
Abstract/Summary:PDF Full Text Request
Objective: Arrhythmia is a serious symptom of heart performance and one of the major causes of death, Viscum Coloratum research Antiarrhythmic effect and its mechanism.Methods: ventricular fibrillation induced by chloroform, barium chloride-induced arrhythmia, myocardial ischemia and reperfusion in rats and arrhythmia aconitine induced arrhythmia, and other models, through experimental observation of Viscum Coloratum on experimental pacemaker disorders role.Results: Viscum Coloratum can significantly confrontation chloroform in mice induced ventricular fibrillation and ventricular fibrillation occurred was significantly decreased (P <0.05, P <0.01) significantly delayed barium chloride-induced arrhythmia in time and shorten the duration of (P <0.05, P <0.01) to reduce coronary artery ligation in rats induced arrhythmia VP arrhythmia frequency and shorten the time (P <0.05, P <0.01) to delay rats induced by coronary artery ligation pacemaker mad VP, VT, VF a time before and after the heart rate and reduce the rate of change (P <0.05, P <0.01) to delay Aconitine premature ventricular contractions induced arrhythmias (VP), a room of Echocardiography speed (VT) and ventricular fibrillation (VF) in time and reduce animal deaths (P <0.05, P <0.01).Conclusion: Viscum Coloratum can be effective against chloroform in mice induced ventricular fibrillation, and to reduce the incidence of ventricular fibrillation in mice. Viscum Coloratum on barium chloride-induced arrhythmias in rats resist, delay arrhythmias in time to shorten the duration of arrhythmia. Viscum Coloratum on Myocardial Ischemia-reperfusion arrhythmia caused a confrontation, VP can reduce the frequency and rate of change in heart rate, shorten the duration of arrhythmia, delayed VP, VT, VF in the time. Viscum Coloratum on aconitine induced arrhythmias in rats resist, delay VP, VT, VF the occurrence of time, reducing animal deaths. To sum up, Viscum Coloratum for a wide range of experimental arrhythmias significantly confrontation role.
Keywords/Search Tags:Viscum Coloratum, anti-arrhythmia, ischemia-reperfusion, VP, VT, VF
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