Effects Of Sufentanil On Postoperative Analgesia And Respiratory Function In Patients With Thoracotomy

objective: To observe the effect of sufentanil on postoperative analgisa and respiratory function in patients with thoracotomy.Methods: Forty patients (ASA I-II) underwent elective thoracotomy were randomly divided into two groups. Group sufentanil (Group S, n=20): received sufentanil 150μg diluted to 150ml for PCIA; Group fentanyl (Group F n=20): received fentany 1.5mg deluted to 150ml for PCIA postoperative respectively. Loading dose, continuous background dose and lock time with the state in accordance with random adjustment. To record VAS score at time point 2h,8h,24h and 48h after operation, to observe the lung function before and 48h after operation, to test C-reactive protein (CRP) and Cortisol (Cor) at the time point of before operation, extubation and 48h postoperation respectively.Results: In group S, VAS scores at 48h postoperation were lower than that in group F, significantly (P<0.05). The postoperative respiratory function in the group S were significant higher than that in group F (p<0.05). There were significant differences in CRP and Cor between two groups. CRP and Cor was lower in group S than that in group F.Conclusion: Sufentanil has a better effect of postoperative analgesia and inhibit stress reaction than fentany1. Postoperative analgesia with Sufentanil can improve postoperative respiratory function.