Study Of The Correlation Of Serum TAOC,MDA,SOD With T2DM Diabetic Peripheral Neuropathy

Objective:To investigate of the correlation of Serum TAOC,MDA,SOD with T2DMdiabetic peripheral neuropathy。Method:serum level of the total antioxidant capacity (TAOC)and Malondialdehyde(MDA)and superoxide dismutase(SOD)were measured in 122 type 2 diabetes and in control group 52 subjects。meanwhile,Their blood pressure,body height, body weight,,serum creatinine(Scr), blood uric acid(UA), highdensity lipoprotein(HDL) ,lowdensity lipoprotein(LDL) ,triglyceride(TG),total cholestero(lTC), serum fibrinogen(FIB), Fasting blood glucos(eFPG),glycosylated hemoglobin(HbAIc) were recorded; body mass index(BMI) were calculated。To use electromyogram to measure nerve conduction velocity( NCV )neuroelectricity electrophysiology normal is non- diabetic peripheral neuropathy(non-DPN)34 subjects;neuroelectricity electrophysiology abnormal is diabetic peripheral neuropathy(DPN)89 subjects。Statistics software SPSS11.5 was used for data processing. All the measurement data was expressed as (mean±standard deviation) and was analyzed by t-test; the numerical data was analyzed by Chi-square test. Logistic regression. was analyzed by means of with or without nodiabetic peripheral neuropathy as dependent variabelity.between two variables use to spearman rank correlation analysis. Results:control group serum level of the total antioxidant capacity (TAOC)and serum level of superoxide dismutase(SOD)is higher than diabetes group,serum level of Malondialdehyde(MDA)is lower than diabetes group。It has statistical significance between two groups(P<0.05)。nerve conduction velocity had statistical significance between two groups(P<0.05)。Body mass index,systolic blood pressure(SBP),diastolic blood pressure(DBP),Fasting blood glucose,triglyceride,total cholesterol,highdensity lipoprotein,lowdensity lipoprotein,serum creatinine,blood uric acid,glycosylated hemoglobin,superoxide dismutase had no statistical significance between two groups(P>0.05)。as well as,age,duration of diabetes,TAOC,MDA,FIB had statistical significance between two groups(P<0.05),Analysis of Logistic regression showed that age,duration of diabetes and MDA level were the positive correlation factor of diabetic peripheral neuropathy(P<0.05)。MDA leval was correlated negative with TAOC,SOD;duration of diabetes,age,FIB was positive correlated with MDA。Conclusions:MDA level, age and duration of diabetescorrelated positively with diabetic peripheral neuropathy; MDA may participate in the development of type 2 diabetic peripheral neuropathy.Banlance disorder between with Oxidation and antioxygen may be one of the reasons diabetic peripheral neuropathy。Otherwise,we should be pay attention to hematic hypercoagulabale state.