A Pharmacological Study On The Chronic Fatigue Syndrome Effect Of Modified Taishan Panshi Powder

Document studiedChronic fatigue syndrome(CFS)is a kind of general syndrome under the contemporary fast tempo mode of live with the serial of chronic fatigue syndromes such as the degression in memory or attention,pain,lymphadenectasis or haphalgesia in cervical part or under armpit,courbature,multi-articular soreness without red swelling of the skin,cephalalgia,somnus unable to recover from fatigue,postexercise defatigation exceeding to 24 hours.CFS is jeopardizing the physical and mental health of people seriously with the ascending tendency in recent years.Hitherto there is no ideal therapeutic measures and drug in modern medicine,the therapy coming from the traditional Chinese medicine shows great prospects.There is no clear-cut records about CFS in the ancient canons of traditional Chinese medicine,but the concepts such as sluggish in four limbs,morbid forgetfulness or deficiency and exhaustion cover part meanings of CFS.According to the viewpoints of doctors in successive dynasties,this kind of syndrome,with the relation to five viscera,results in insufficiency and blockage of vital energy and blood.Because of the function of qi of the spleen and stomach to transfer activities of qi and to regulate vital movement,Neijing thinks of the spleen and stomach as the key point in the mechanism of CFS.Modern Medicine is lack of specificity treatment to cure CFS. At present,we could only rely on clinical symptoms to make diagnosis of CFS.Because the disease often can not be detected by laboratory examination.Modified Taishan Panshi Powder comes from an ancient Chinese medicinal formul.The power has effectiveness about invigorating the spleen and dispersing the stagnated liver-energy,reinforcing kidney to strengthen bones,and nourishing qi and blood.As making a prominent effect,it is being used in the treatment of CFS.This investigation's foothold is the study on pharmacology of Modified Taishan Panshi Powder. So it can provide scientific evidence for its clinic appliance, and make further development and utilization for the pharmacological foundation research.The objective of this investigation is to study the effect on anti-fatigue and anti-hypoxia and immue of Modified Taishan Panshi Powder.Therefore,this investigation is mainly about the pharmacological aspect content of the formula,these comprise in detail:Exeriment studied1 Experiment about Anti-fatigue effectsObjective:To study the effect on anti-fatigue of Modified Taishan Panshi Powder.Methods:Mices swimming time and climbing time were calculated.Results:Middle-dose and high-dose Modified Taishan Panshi Powder could obviously extend swimming ahd climbing time by tests on mice.Conclusions:Modified Taishan Panshi Powder has anti-fatique function.2 Experiment about Anti-hypoxia effectsObjective:To study the effect on Anti-hypoxia of Modified Taishan Panshi Powder.Methods:Mices enduring time under normal pressure in a hermetical container and the enduring time about intoxication were calculated.Results:Middle-dose and high-dose Modified Taishan Panshi Powder could extend survival time by tests on mice.Conclusions:Modified Taishan Panshi Powder has anti-hypoxia effects. 3 Experiment about immunoloregulation effectsObjective:To study the effect on immunoloregulation of Modified Taishan Panshi Powder.Methods:Phagocytosis of mononuclear macrophage was determined with carbon particle clearance test.Results:Middle-dose and high-dose Taishan Panshi Powder could performed a remarkable function on Phagocytosis of mononuclear macrophage by tests on mice.Conclusions: Modified Taishan Panshi Powder has immuneregulation function.4 Experiment about animal model' biochemistry testObjective:To study the biochemistry test about the CFS animal model of Modified Taishan Panshi Powder.Methods:Use of physical stress and psychological stress to establish animal models of CFS, to test its urea nitrogen,blood lactate and the glycogen content. Results:Modified Taishan Panshi Powder could increase glycogen content reserves,reduce urea nitrogen content and blood lactate levels.Conclusions:Modified Taishan Panshi Powder has anti-fatique function.5 Experiment about emergency toxicology effectsObjective:To study the effect on emergency toxicology of Modified Taishan Panshi Powder.Methods:to Test The largest amount of administration.Results:The largest amount of administration of Modified Taishan Panshi Powder was 72.4 g/kg,equivalent to the amount of 624 adults on the times and found no obvious acute toxicity.Conclusions: As an Oral medication,Modified Taishan Panshi Powder is basically security.