The Experimental Study Of One-piece PMMA Keratoprosthesis Implanted Into Alkali Burned Rabbit Corneas

Objective:We developed two new types one-piece keratoprosthesis(KPro)made of PMMA The aim of this study was to evaluate biological response to the PMMA material as skirt of one-piece Kpro and also to assess the long term clinical outcomes of Kpro implanted to alkali burned rabbit corneas,including Kpro designs, operative methods and compalications.Methods:By taking use of artificial cornea with an optical region surrounded by skirt was fabricated,The discs of PMMA were inserted into the tamellar pocket of twelve alkali-burned corneas and the corneas were observed clinically at various time.Two Kpros were implanted in alkli burned corneas and followed up.Results:One-piece KPros have been retained during the experiment without severe complications such as cataract,retinal detachment and extrusion.Condusion:PMMA material is suitable for making one-piece KPros with low complications.The new Kpros have shown advantages,especially in operative procedures.The preliminary results were satisfactory,...