Investigation Of Ultrasound Contrast Sonogram On Acute Gastric Mucosa Injury In Dogs By Using The New Type Ultrasound Contrast Agent

Objective Acute gastric mucosa lesion is one of the common disease inEmergency Department, and integral organs complication after wounding ,which could threaten patients lives.. In recent years, there is no effective diagnose method in clinic about severe patients to put together gastrointestinal trace disease. Though we could have traditionary detection method on morphology of stomach intestine including barium meal and Endoscopy of stomach intestine, there are surely confined frequent. This experiment makes use of a new type gastric ultrasound contrast agent which is own invented, investigating to develop an imaging stomachs of SD rats and dogs by gastric ultrasound contrast. To investigate the appearance of ultrasound contrast sonogram in acute gastric mucosa injury..Methods Forty-two Sprague-Dawley (SD) rats were randomly allocated intotwo groups. The first group is the control group, each SD rats was poured in the Wei-chuang UCA through gastric tubes. The second group each SD rats was poured in the new type UCA through gastric tubes. We picked out the best new type gastric UCA through these experiments. 16 adult hybird dogs were randomized into a normal control group and an experimental group. Acute gastric mucosa injury models were made in the experimental group. The gastric ultrasound sonogram was observed and recorded after each dog was poured in the new type UCA through gastric tubes. The stomachs of two groups dogs were cut out, and their stomach tissues were cut into slices, dyed, and observed under microscope which would be compared with sonogram.Results The research shows: the new type UCA group compared with Wei-chuang UCA group (P>0.05) ,there were no obvious difference. The ultrasound sonogram showed that the stomachs of dogs in the control group were filled with UCA well, the structure of gastric wall could display clearly on 5 layers -"strong-weak- strong-weak-strong"; Comparing with the control group, the sonograms of the experimental gastric antrum wall in dog displayed much thicker, and the first, second and three-tier were mixed each other resulting in more strengthener echo. The structure of gastric wall in the normal and acute gastric mucosa injury of dogs could display clearly by gastrointestinal contrast ultrasound.Conclusion Gastrointestinal contrast ultrasound.have a diagnostic value on acutegastric mucosa injury. It is very significance that gastric ultrasound contrast act as an important clinic method for diagnosing gastrointestinal trace disease.