The Clinical Value Of Dynamic Monitoring Inhibin A Levels In The Prediction Of Early Threatened Abortion

Objective: The clinical valve of dynamic monitoring serum and morning urinary inhibin A levels in the prediction of early threatened abortion.Methods: 64 cases of pregnant women between 5～12 weeks,20 cases of normal pregnancy,30 cases of early threatened abortions due to luteal phase deficiency and 14 cases of inevitable abortions were observed between January 2007 and November 2007 in the out patient department of gynecology of the first affiliated hospital of Soochow University.The concentration of serum levels of inhibin A,progesterone,β-human chorionic gonadotropin and morning urinary inhibin A were measured using ELISA.Results:①In normal pregnant women,the serum inhibin A levels showed obvious increase from 5 weeks,and continued up with the gestational age.The mean level of INHA of 8～10 weeks was 720.13±92.16pg/ml,and gradually decreased after 10 weeks;②In cases of abortion the serum inhibin A levels were obviously lower than the control group and continued pregnancy group(P<0.001),these were no difference between the continued pregnancy group and the control group(P>0.05);③According to ROC curve, the serum inhibin A levels over 154.95pg/ml has the best sensitivity(91.7%) and specificify(90.0%),so it can be used as an efficient index for prediction of early threatened abortion ;④The morning urinary inhibin A levels cannot be detected between 5～6 weeks;and very low levels can be detected between 8～10 weeks, the level of the control group was 32.40±7.21pg/ml and the continued pregnancy group was 32.83±6.52pg/ml;⑤The serum inhibin A level was positively correlated with the morning urinary inhibin A level at 8～10 weeks,the correlation coefficient of it with the the control group was 0.79(P<0.001), was 0.604(P=0.002) with the continued pregnancy group;⑥The serum inhibin A levels had no significant correlation with progesterone andβ- human chorionic gonadotropin levels in early pregnancy.Conclusions: The decreased inhibin A levels can predict threatened abortion in early pregnancy.The serum inhibin A levels can be used as an efficient index for prediction of early threatened abortion and prevent miscarriage during if the serum inhibin A level was over 154.95pg/ml.Very low inhibin A levels can be detected in the morning urine of pregnant women with 8～10 weeks.