The Changes Of Serum-related Hormones Levels In4to9Weeks’ Pregnant Women With Different Outcomes

Objectives To investigate the difference of the pregnancy-related hormones among thedifferent early pregnancy outcomes, including human chorionic gonadotropinh(hCG),progesterone(P), estrone(E2), and testosterone(T). And analysis the change of the fourhormones with the progress of gestational week.Methods314early single intrauterine pregnant women were chosen to make aquestionnarie survey. They were all not suffering from medical complications, and werefollowed up to the3rd month pregnancy. The fasting serum levels of hCG, P, E2and Twere all checked in all pregnant women by the method of chemiluminescence. At the endof the survey, all of them were divided into4groups according to the early pregnancyoutcome. These groups were named as normal pregnancy group, threatened abortiongroup, inevitable abortion group and missed abortion group respectively. The software ofSPSS16.0was used to analysis the difference of4hormones among4groups.Results1Among the314pregnant women,167cases(53.18%) had not any abnormalsymptom during pregnant period and were named as normal pregnancy group,147abnormal pregnancy cases (46.82%) were named as abnormal pregnancy group. In theabnormal pregnancy group,102cases (69.39%) who suffered from threatened abortionwere named as threatened abortion group,29cases(19.73%) who suffered frominevitable abortion were named as inevitable abortion group,16cases (10.88%) whosuffered from missed abortion were named as missed abortion group, The earlypregnancy loss occur14.33%(45/314) in our survey.2The serum levels of hCG, E2, Tare positively related to the week of pregnancy (serum hCG: r=0.57, P=0.00; serum E2:r=0.62, P=0.00; serum T: r=0.24, P=0.00), but the serum level of P is unrelated with thegestational week (r=0.15, P=0.06).3The95%confidence interval of serum P is (81.98～90.50)nmol/L in normal pregnancy, and the95%confidence interval of serum E2level is(2826.2～3383.0)pmol/L.4Within the same gestational weeks, serum E2level of normalpregnancy group is higher than that of abnormal pregnancy group (P<0.05).5It canimprove the sensitivity of diagnosis for abnormal pregnancy by combining detection of4hormone levels to94.83%.Conclusions1The serum levels of HCG, E2and T of normal pregnancy are positivelyrelated to the week of pregnancy, but the level of P does not change along with the weekof pregnancy.2Within4to9weeks of pregnancy, serum E2level of normal pregnancygroup is higher than that of abnormal pregnancy group.3Combined detection of serumhCG, E2, P, and T levels in early pregnancy is more conducive to predict pregnancyoutcomes.