The Changes Of Biochemistry And Routine Parameters In Blood Under Fracture Trauma Stress

Stress is a kind of general physical and adaptive response during the body is stimulated by a stressor, it can produce a significant defense and compensation system in the body. It is well-known that adequate stress is profit to the body, ensure the potency of the body be activated to meet the alternation of internal environment. However, prolonged or increased magnitude stress responses could cause the tissue injury with a significant cost to the health of the individual, moreover, lead to some stress diseases. Stress response is regulated by the interactions of nervous system, endocrine system and immune system, the response is also related to many other systems. The increased secretion of certain hormones and cytokines when the individual is under stress which ultimately alter the function and metabolism of virtually all organ system and may lead to the changes of biochemistry and routine parameters in blood. Fracture trauma is easy to diagnose, and the stress caused by fracture trauma is considered as an approval model of stress. This model is available to research the mechanism of stress response perfectly. We try to find the correlated markers of stress through studying the coherent parameters of blood, hepatic function and renal function of the individuals who got fracture trauma. Meanwhile, we'll make a reasonable evindence of the precaution and therapia of stress diseases through the research the rules of the changes of biochemistry and physiology, and the followed pathologic alteration.Method1. Groups and methods: 34 patients (male 24, female 10) of the multiple fracture trauma, aged between 20- 46, were selected as the trauma stress group. And 34 healthy person whose sex and age were same with the stress group ,were defined as the control group. All of those were took venous blood on an empty stomach, and finished the examination of biochemical and rout parameters in the same laboratory.2.The parameters: high-sensitive C– reactive protein(hs-CRP), blood glucose(BG), total protein(TP), albumen(AL), total bilirubin(BRT), direct bilirubin(BRD), indirect bilirubin(BRID), total bile acid(TBA), GPT,GOT, alkaline phosphatase(ALP), serum creatinine, urea of serum, serum uric acid, serum total calcium, serum phosphorus, serum magnesium, WBC, absolute value of neutrophilic leucocyte, absolute value of lymphocyte, RBC, HB and PLT.Result:The levels of CRP, BG, TBA, GOT, WBC, and absolute value of nutrophilic leucocyte of the trauma stress group is increased, compared with the control group, there is a statistic significance between those groups (P<0.05) .The levels of TP, AL,ALP, serum uric acid, serum calcium, serum magnesium, RBC and HB is decreased in the trauma stress group, and there is significant difference between the stress group and the control group. (P<0.05).There are not statistical differences apparently between the two groups on the levels of other parameters.Conclusion1. Stress could cause the changes of biochemical and rout parameters in blood. This alteration may be related to all aspects of neuroendocrine system.2. Hepatic function and renal function may be controlled by the neuroendocrine system.3. The parameters of biochemistry and routine in blood may be defined as the significant markers. Mainly include: Blood glucose, CRP,AL,ALP, TBA, urine acid, serum calcium, serum magnesium, WBC and absolute value of neutrophil.