Influences Of Mental Health Status On The Routine Laboratory Indexes And Their Correlations With The Allelomorphic Genes Of HLA-DQB1

Objective: To explore the relationship between the mental health and the body health through analyzing the correlation between each index of SCL-90 and the routine laboratory indexes, and investigate the correlation between the allelomorphic genes of HLA-DQB1 and the mental health, to find the influences of mental health status and the differences of indivi- duality on the development process of disease.Methods:1. Forty-nine individuals with abnormal mental health (judged by SCL-90) and 31 with normal mental health were selected. Furthermore, 20 individuals with highest score of every index in SCL-90 were separated as high score group and 20 with lowest were separated as low score group. Routine laboratory indexes were tested by auto equipment. The differences between two groups of each index in SCL-90 were analyzed to investigate the correlation between the mental health and the body health.2. Fifty physical examination people with abnormal mental health (judged by SCL-90) and 37 with normal mental health were selected as abnormal mentality group and control group respectively. Routine labo- ratory indexes were tested by auto equipment. HLA-DQB1*02, *03, *04, *05, *06 alleles were individually amplified by polymerase chain reaction (PCR) using exon 2 group-specific primers, its correlation with routine laboratory indexes and mental health status were investigated.Results:1. Statistical analysis showed significant differences in each index of SCL-90 between the stress people and normal people. 2. Statistical analysis showed significant correlation, the differences in the results between some routine laboratory indexes and indexes of SCL-90 is significant (P<0.5). RBC, PCT, AST, Cre and A/G were higher and MCV, MCH, MCHC, MPV, Glob, TP, TG, HDL and LDL were lower in high score group, compared with low score group. RBC, MCV, MCH, PLT, Glob, TP, HDL have significant correlations with several indexes of SCL-90 individually.3. Statistical analysis showed significant difference in the distributed frequency of HLA-dqb1*02 (P<0.5) between two groups. The PLT and PCT in abnormal mentality group were significantly higher than that in control group (P<0.5), while the MCV, MCH, MCHC and HDL was significantly lower (P<0.5). The mental health status and HLA-DQB1*02, *03, *04, *05, *06 alleles have significant influences on some different laboratory indexes (P<0.5). Compared with control group, WBC, LYMPH, MONO, RBC, PLT and PDW were higher and LYMPH%, HB, HCT and MPV were lower in abnormal mentality group.Conclusion: The abnormal mental health could induce some routine laboratory indexes change and this is maybe related with the phenotype of HLA-DQB1.