Study On Active Constituents Of Liriope Platyphylla Wang Et Tang

Liriope platyphylla Wang et Tang,which is a Chinese folk medicine,is the tuberous root of Liriope platyphylla Wang et Tang,and it is often used for treatments of hemoptysis, diabetes,constipation and throat pain.It is distributed in many provinces of China.With the popular progress of modern science life,more and more people begin to realize the importance of healthcare field.A growing number of people believe that natural products will be the best choice to cure disease and keep healthy.It is reported that only a few saponins have been isolated from the tuberous root of Liriope platyphylla Wang et Tang until present time.Further studies on the Liriope platyphylla Wang et Tang led to the isolation of fifteen compounds from the extract of the tuberous root.This paper including seven parts research.1.Through the research advancement on the chemical and pharmacology of Liriope Lour,we collected all the research and development of Liriope Lour,which can provide the basement the research of Liriope platyphylla Wang et Tang.2.The structures of twelve compounds were elucidated on the basis of chemical and spectral analysis(IR,MS,GC,¹H-NMR,¹³C-NMR and 2D-NMR).They were:Sub1:β-sitosterolSub2.β-sitosterol-3-O-β-D-glucopyranosileSub3:ursolic acidSub4:lupeolSub5:lupenoneSub6:diosgeninSub7.ruscogeninSub8:25(S)-ruscogenin 1-O-β-D-xylopyranoside-3-O-a-L- rhamnopyranosideSub9:Ruscogenin 3-0-a-L-rhamnopyranosideSub10:25(S)-ruscogenin 1-O-β-D-fucopyranoside-3-O-a-L- rhamnopyranosideSub11:25(S)-ruscogenin 1-O-a-L-rhamnopyranosyl(1→2)-β-D-fucopyranoside.Sub12:Ruscogenin 3-O-β-D-glucopyranosyl(1→3)-a-L-rhamnopyranoside.Among these compounds,Sub1,Sub2,Sub3,Sub7 and Sub8 were obtained from this medicine for the first time.In addition,Sub4,Sub5 and Sub6 were obtained from this genus for the first time. 3.In this paper,the extraction methods of total saponins of Liriope platyphylla Wang et Tang(Lpts) was also studied.4.Research on anti-aging of total saponin of Liriope plalyphylla Wang et Tang(Lpts). The experiment showed that Lpts may play an important role in preventing anti-aging effect.In this paper,compound saponin B has cardiovascular and cerebral vascular bioactivity.5.ELSD-HPLC has been established to determine the quantity of saponin B in total glycoside in this paper.6.Research and develop the Liriope platyphylla Wang et Tang soft capsule.The component of this soft capsule including the total saponins of Liriope platyphylla Wang et Tang.,tea polyphenols and food oil.7.Research on safety of Liriope platyphylla Wang et Tang soft capsule.The experiment showed that this soft capsule is safety.