The Association Of The Effects Of Risperidone And Olanzapine On The Glucose And Lipid Metabolism And The Polymorphism Of 5-HT2C Gene-759C/T And Leptin Gene-2548G/A

Objective1. To compare the different effects of risperidone and olanzapine on glucose and lipid metabolism.2. To determine associations between weight gain induced by antipsychotic and the polymorphisms of 5-HT2C gene -759C/T and leptine gene -2548G/A.Methods102 schizophrenic patients who met Chinese classification of mental disorder were divided into risperidone group and olanzapine group. Before and after twelve-week treatment, some data which include height, body weight, the fasting glucose, the fasting serum insuline, leptin, adiponectin, total cholesterol and triglyceride were measured. In addition, the body mass index (BMI), insulin resistance index (IRI) were calculated. The ligation diction reaction technique was used to analysis the frequencies of 5-HT2C gene -759C/T and leptin gene -2548G/A polymorphisms.Results 1. After treatment, the BMI, fasting serum insulin, the IRI and leptin levels increased significantly in rispeeridone and olanzapine groups and the fasting glucose and adiponectin levels did not increase or decrease significantly.2. The concentrations of total cholesterol and triglyceride significantly increased in olanzapine group and did not increase in risperidone group.3. The increased level of BMI, fasting insulin, IRI, total cholesterol, triglyceride and leptin was significantly higher in olanzapine group than that in risperidone group. There was not any difference in the increased level of adiponectin and fasting glucose in olanzapine and risperidone groups.4. The patients with 5-HT2C gene -759C and -759CC were gained more weight than those with -759T and -759TT/CT after antipsychotic treatment.5. The patients with -2548AA of leptin gene were gained more weight than those with -2548AG and -2548GG of leptin gene after antipsychotic treatment.6. The patients with -2548AA of leptin gene had higher leptin level than those with -2548AG and -2548GG of leptin gene after antipsychotic treatment.Conclusions1. Risperidone and olanzapine could induce weight gain and dysfunction of glucose metabolism. The effects of olanzapine on the glucose metabolism outweight those of risperidone.2. Olanzapine have some effects on the lipid metabolism and risperidone have no effect on lipid metabolism.3. The -759C/T polymorphisms of the promoter region of 5HT2C receptor gene and -2548A/G polymorphisms of leptin may be associated with antipsychotic induced weight gain.