Comparative Study Of Fibrous Dysplasia And Osteofibrous Dysplasia

Fibrous dysplasia and osteofibrous dysplasia are both benign fibro-osseous lesions of the bone .Histologically, the features of these bone lesions sometimes look quite similar, but their precise nature remains controversial. We reviewed the two diseses from pathogenesis, pathology, diagnosis and therapy.Fibrous dysplasia of bone is a non-inheritable disease, characterized by bone pain, bone deformities and fracture, involving one or several bones. It is caused by mis-sense mutations occurring post-zygotically in the gene coding for the alpha-subunit of the stimulatory G-protein, Gs, in the guanine nucleotide binding, alpha stimulating (GNAS) complex locus in chromosome 20q13.The pathogenesy of Osteofibrous dysplasia has not been identified, some studies suggests that osteofibfous dysplasia is an autosomal dominant inheritance tumor. It almost exclusively affects the tibia, and focal lump is the symptom.