Study Of Serum Interleukin-18 Level In The Patients With Colorectal Carcinoma And Its Clinical Significance

Objective Interleukin-18(IL—18)is a new cytokine,it's inclued mainly by macrophage and dendritic cell.Some study showed IL—18 has a important role in some patients with cancers.We investigate the clinical significance of serum IL-18 levels in the patients with colorectal carcinoma.Methods The serum IL-18 level was detected by enzyme-linked immunosorbent assay(ELISA)in 48 cases of colorectal carcinoma and 48 healthy controls.Results The mean serum IL-18 level was significantly higher in patients with colorectal carcinoma than in the healthy control(P＜0.05).The serum IL-18 was much higher in patients with each stage disease than in the healthy control(P＜0.05). The serum IL-18 was much higher in patients with stageⅢand stageⅣdisease than in patients with stageⅠ(P＜0.05).Conclusion The serum IL-18 level has a close correlation with the clinical stage,globate glands metastasis and tumor infiltrating depth.The serum IL-18 level may be used an important tumor marker in screening colorectal carcinoma,preoperative staging and monitoring recurrence.