The Clinical And Experimental Research Of Method Of Invigorating Kidney And Promoting Blood Circulation In Treating The Left Ventricular Hypertrophy Caused By Hypertension

Objective: To observe the improving effects of Sangshen Jiangya capsule whose effect is to invigorate kidney qi and promote blood circulation to dredge collaterals on left ventricular hypertrophy caused by hypertension and to explore the effect mechanism. Methods: The clinical research using layered randomly grouping means, divided patients into two groups, namely Sangshen Jiangya capsule group, 30 cases, and Captopril control group, 22 cases.The period of treatment is 12 weeks.Results:In clinical research it has been proved that Sangshen Jiangya capsule can lower blood pressure preferably, improve clinical symptom, adjust vaso-active substance, ameliorate insulin resistance, rectify metabolic disorder of lipid, reduce blood viscosity and decrease the weight index of left ventricle, thus can improve left ventricular hypertrophy caused by hypertension.The animal experiment indicates that Sangshen Jiangya capsule can lower the blood pressure ,heart rate and ratio of left ventricle weight to body weight of spontaneously hypertensive rats, adjust vaso-active substance, ameliorate insulin resistance, reduce blood viscosity , counter coagulation, and restrain hypertrophy of myocardial cell. The statistics indicates that Sangshen Jiangya capsule surpasses Captopril on such aspects as improving clinical symptom , ameliorating insulin resistance and reducing blood viscosity, and is equivalent to Captopril on controlling blood pressure and reducing the weight index of left ventricle. Conclusion: Through controlling blood pressure, adjusting vaso-active substance, ameliorating insulin resistance,improving myocardial ischaemia, reducing blood viscosity and countering coagulation, Sangshen Jiangya capsule effectively prevent and cure the occurrence and development of left ventricular hypertrophy caused by hypertension.So it is the fine medicine in prevention and cure of hypertension and its complication. Thisresearch advises that kidney-asthenia and blood stasis is the important pathogenesis of left ventricular hypertrophy caused by hypertension and invigorating kidney and promoting blood circulation is its important method of therapy.And it provides the theoretical basis for treatment based on the differential diagnosis of complication caused by hypertension.