Clinical Study On The Effect Of CRP,IL-6,IL-8,TNF-α During Severe Acute Pancerititis

Objective To evaluate changes of the inflammatory factors during Severe acute pancerititis (SAP) including tumor necrosis factorα(TNF-α), interleukin-8(IL-8),interleukin-6 (IL-6) and C reactive protein (CRP), and at the same time to investigate their diagnostic value for SAP predication. Methods 15 cases of SAP patients and 30 cases of normal acute pancerititis (AP) diagnosed in Peoples Hospital of Xinjiang Uyger Autonomous Region between November 2007 to April 2008 were enrolled in this study,and another 20 healthy volunteers were set as normal contrals. 5 ml venous blood was extracted in each subject both pre and post treatment respectively, and serum was separated for TNF-α, IL-8, IL-6 and CRP determanation. Result TNF-α, IL-8, IL-6 and CRP were singnificantly increased in SAP patients than in AP patients and in healthy contrals before treatment(P<0.05), but there was no singnificant differences exsist between pre trement and post treatment in SAP patients(P>0.05). Conclusion IL-6 and CRP probably will predict the prognosis and the severity of paients with SAP, and at the same time may do some help for judgement of SAP reatment. But TNF-αand IL-8 will be fourthly tested both in its illness predication and t reatment evalution.