The Expression And Significance Of P-STAT3 And VEGF Proteins In Psoriatic Lesions

Objective: To study the expression and the significance of P-STAT3 and VEGF proteins in psoriatic skin lesions.Methods: The biopsies were taken from skin lesions in 35 patients with psoriasis vulgaris and the skin of 16 normal controls, the expression and distribution of P-STAT3 and VEGF proteins were detected by immunohistochemical method.Results:①The level of P-STAT3 proteins in lesional skin of psoriasis patients is 156.4±11.35, which is significantly higher than that in normal controls (205.6±10.3, P<0.01). The strong positive expression of P-STAT3 proteins in the active stages of psoriasis vulgaris is 142.3±9.11, but in resting stages is 168.1±9.89. There are significant differences between them (P<0.01).②The level of VEGF proteins in lesional skin of psoriasis patients is 151.6±8.21, which is significantly higher than that in normal controls (198.2±9.75, P<0.01). The strong positive expression of VEGF proteins in the active stages of psoriasis vulgaris is 138.4±9.32, but in resting stages is 159.5±8.11. There are significant differences between them (P<0.01).③There is significant positive correlation between the expression of P-STAT3 and VEGF proteins in the skin lesions (the correlation coefficient is 0.74, P<0.01 ). There is significant positive correlation between the expression of P-STAT3 proteins in psoriatic lesion and PASI index (the correlation coefficient is 0.54, P<0.01), but no correlation between the expression of VEGF proteins in psoriatic lesion and PASI index (the correlation coefficient is 0.31, P>0.05).Conclusion:①The expression of P-STAT3 and VEGF proteins in psoriatic skin lesions are significantly higher than that in normal controls, suggesting that they are involved in the pathogenesis of psoriasis.②The expression of P-STAT3 proteins in the active stage of psoriasis vulgaris is significantly higher than that in the resting stage, and P-STAT3 proteins is positive correlated with PASI index, suggesting that P-STAT3 proteins is not only correlated with the stages of psoriasis vulgaris, but aslo correlated with the severity. The expression of VEGF proteins in the active stage of psoriasis vulgaris is significantly higher than that in the resting stage, but there is no correlation between VEGF proteins and PASI index, suggesting that VEGF proteins is correlated with the stages of psoriasis vulgaris, but is not correlated with the severity.③There is significant positive correlation between the expression of P-STAT3 and VEGF proteins in the psoriatic lesions, suggesting that VEGF gene may be regulated directly by STAT3 protein.