| Objective:1. To analyze incidence of hypertensive disorders complicating pregnancy(HDCP) and its complications in the last year in our hospital.2. To analyze the relationship between hypertensive disorders complicating pregnancy and social or obstetric factors.3. To compare the effects on perinatal infants induced by various grade of hypertensive disorders complicating pregnancy.4. To analyze the effects on perinatal infants while hypertensive disorders complicating pregnancy is complicated by hypoproteinemia.Methods:Retrospectively analyzed 289 cases of inpatient childbirth between October 1, 2007 and October 1, 2008 at the First Clinical Hospital of Jilin University and its branch,among them 97 cases were diagnosed as hypertensive disorders complicating pregnancy (HDCP) and are classified according to the criterion in , the first edition of eight-year teaching material,26 cases of mild pre-eclampsia, 64 cases of severe pre-eclampsia and 7 cases of eclampsia are classified. By retrospectively analyzing the 97 cases of pre-eclampsia and eclampsia, clarify the incidence of HDCP, its associated risk factors and its negative effects complications on the pregnant women and prenatal infants.Results:1. Incidence of various grade of HDCP: among the 289 cases of inpatient childbirth in the last year, 97 cases were diagnosed as pre-eclampsia or ec -lampsia, the incidence of HDCP was 33.56%, 26 cases of mild pre-eclampsia accounted for 26.8% , 64 cases of severe pre-eclampsia accounted for 65.98% and 7 cases of eclampsia accounted for 7.22%. Severe pre-eclampsia and eclampsia in the proportion of patients accounted for 73.2% incidence.2. HDCP and social or obstetric relevant factors:2.1 Age: in 97 cases of patients with HDCP, 27 cases were under 25-year -old, 40 cases were between 26 to 34 years old, 30 cases were more than 35-year-old, compared the incidence of HDCP in different age groups,P>0.05, the difference was not statistically significant.2.2 place of residence: rural patients 52 cases, urban patients 45 cases, incidence proportion of severe pre-eclampsia and eclampsia were higher in rural patients than in urban patients. Compared the incidence of HDCP in urban and rural groups, P<0.05, the difference had statistical significance.2.3 If a systematic prenatal physical examination has been carried out: 22 cases of HDCP patients had carried out a systematic examination, 75 cases hadn't. Patients who hadn't carried out a systematic examination accounted for more and more incidence proportion while HDCP became more and more severe. Compared the incidence of HDCP in those two groups who had or hadn't carried out a systematic prenatal physical examination, P<0.05, the difference had statistical significance.2.4 The history of abortion: 45 cases had a history of abortion,52 cases had not. Severe pre-eclampsia occupied a higher incidence proportion in abortion group, 71.11 percent. Compared incidence of HDCP in the two groups, P>0.05, the difference was not statistically significant.2.5 Parity: 62 cases were primipara, 35 cases were multipara. Incidence of HDCP was higher in primipara group, while incidence proportion of severe pre-eclampsia was higher in multipara group. Compared the incidence of HDCP in primipara and multipara groups, P<0.05, the difference had statistical significance.2.6 multiplets or not: in 97 cases of HDCP, 89 cases were single birth, only eight cases were twins. Compared incidence of HDCP in the two groups, P>0.05, the difference was not statistically significant.3. incidence and incidence proportion of complications: in 97 cases of HDCP patients, 73 cases had no complications, 24 cases had, of which 21 cases complicated by one kind of complications, two cases complicated by two kinds of complications, 1 case complicated by four kinds of complications. The incidence of various complications from high to low as followed: placental abruption, retinopathy, acute renal insufficiency, placenta praevia, HELLP syndrome, acute heart failure, ascites. Placental abruption and HELLP syndrome had the highest incidence in eclampsia group, and acute renal failure, acute heart failure and ascites had the highest incidence in severe pre-eclampsia group, retinal lesions and placenta praevia had the highest incidence in mild pre-eclampsia group.4. The effects on perinatal infants induced by HDCP: in 97 cases of HDCP perinatal infants, 50 cases of premature infants,33 cases of neonatal asphyxia, incidence of preterm infants and the neonatal asphyxia increased along with the aggravation of HDCP. There were 32 cases of FGR, 6 cases of stillbirth, 13 cases of perinatal infants death, the highest incidence of these three diseases were all in severe pre-eclampsia group, while 24 cases of respiratory distress of newborn fetal had the highest incidence in eclampsia group.5. The effects on perinatal infants while HDCP is complicated by hypop- -roteinemia.5.1 Termination of pregnancy and perinatal infants weight: both termination age of pregnancy and fetal weight in hypoproteinemia group were lower than non-Hypoproteinemia group, both P values were < 0.05,differences were statistically significant.5.2 Incidence of perinatal asphyxia: in Hypoproteinemia Group perinatal asphyxia rate was 31.25%, higher than non-Hypoproteinemia group (21.21%),but the difference between the two groups was not statistically significant, P>0.05. 5.3 Incidence of FGR: Incidence of FGR in hypoproteinemia group was 40.63%, significantly higher than non-Hypoproteinemia group (18.18%), P<0.05, the difference had statistical significance.5.4 stillbirth rate and the perinatal mortality: in hypoproteinemia group, stillbirth rate was 9.38%, the perinatal mortality rate was 15.63%,both were higher than non-Hypoproteinemia group (stillbirth rate 0, the perinatal mortality rate 9.09 %), but both P values were >0.05, the difference was not statistically significant.Conclusion:1. Incidence of HDCP in my hospital was higher than average level in our country, serious cases accounted for the larger proportion, incidence of complications are also higher, and are associated with the severity of the disease.2. Incidence of various degrees of HDCP are associated with pregnant women residence (urban or rural), systematic prenatal physical examina- -tion and parity (primipara or multipara), but have nothing to do with age, history of abortion, nor multiplets.3. Pregnant woman who are multipara, living in rural areas or hadn't carried out a systematic prenatal physical examination has a higher risk of serious HDCP .4. More serious HDCP bring the more negative impact on the perinatal infants.5. HDCP complicated by hypoproteinemia earlier termination age and lower perinatal weight than those without hypoproteinemia.6. HDCP complicated by hypoproteinemia will make incidence of perinatal FGR significantly increased, but incidence of perinatal asphyxia, the stillbirth rate and perinatal mortality was no significant impact.
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