The First Exploration Of The Progesterone Receptor Isoforms Expression In The Placenta Of Hypertensive Disorders Complication Pregnancy

The First Exploration of the Progesterone Receptor Isoforms Expression in the Placenta of Hypertensive Disorders Complicating PregnancyBackground:Hypertensive disorders complicating pregnancy remains a leading cause of maternal death and perinatal morbidity and still the pathophysiological mechanisms of the disease remain largely unknown.Objective:To study the expression of progesterone receptor isoforms ( PRs) in the placenta of hypertensive disorders complicating pregnancy(HDCP) and normal pregnancy.Method:Using electrophoresis and RT-QPCR technique, the expression of PR-(A +B) and PR-B mRNA were examined in normal pregnancy (15 cases ) and preeclampsia(25 cases ) in the obstetric department of the second hospital of Jilin university.Results:(1) Expression of PR mRNA in preeclampsia were significantly lower than those in normal pregnancy ( P < 0.05) ; (2) The special expression of PR-C has no association with HDCP(P>0.05); (3)The ratio of PR-B/PR-(A+B) mRNA has no significantly difference between normal pregnancy and HDCP(P>0.05).Conclusion:(1) The low expression of PR may be related to HDCP;(2) The special expression of PR-C has no association with HDCP;(3) The ratio of PR-B/PR-(A+B) mRNA may be not related to HDCP.