Intestinal Mucosal Barrier Changes And Clinical Significance In Children With Henoch-Schonlein Purpura

Objective:To investigate the changes and clinical significance of intestinal mucosal barrier in children with Henoch-Schonlein purpura(HSP).Methods:The blood samples were collected from 60 children with Henoch-Schonlein purpura and 30 normal children.In the isolated plasma, the levels of determine diamine oxidase(DAO),D-lactic acid and endotoxin were measured with spectrophotometric.Result:The levels of plasma diamine oxidase,D-lactic acid and endotoxin before treatment in HSP group were higher than in the normal control group,the difference was statistically significant(P＜0.01).The levels of plasma diamine oxidase,D-lactic acid and endotoxin before treatment in HSP group with gastrointestinal symptoms were higher than in HSP group without gastrointestinal symptoms and control group.There was a significant difference between each other(P＜0.01,LDS).To compare the measured results of plasma diamine oxidase,D-lactic acid and endotoxin before and after treatment,there were significant difference(t≥2.556,P≤0.009)between HSP with gastrointestinal bleeding and without gastrointestinal bleeding,and there was no significant difference(t≤1.753,P≥0.095) in HSP group without gastrointestinal symptoms.Conclusion:The damage of mucosal barrier function was exist in children,especially in HSP group with gastrointestinal symptoms.After treatment,the intestinal mucosal barrier was restored gradually.