Discussion On The Combining Testing Of Serum Levels Of CEA, CA125, CYFRA21-1, SCC-Ag, TSGF For The Clinical Value In Non-Small Cell Lung Cancer Diagnosis

ObjcetiveTo study the clinical significanee and appreciation of therapeutic effcet of combined measurement of carcinoembryonic antigen (CEA), carbohydrate antigen 125(CA125),cytokeratin 19 fragements(CYFRA21-1), quamous cell carcinoma antigen(SCC-Ag) and tumor associated growth factor(TSGF) in the diagnosis of lung cancer, the aim of this study is to evaluate the role of the combined detection in the diagnosis of lung cancer.Materials and MethodsSerum levels of CEA,CA125,CYFRA21-1,SCC-Ag and TSGF in 56 patients with NSCLC in different TMN stages and 35 patients with benign lung diseas were measurde by chemoluminescence, ELISA and chromatometry methods respectively. The NSCLC patients were further divided into squamous cell carcinoma subjects and adenocareinoma patients. All cases had been proved by pathologic diagnosis and previously untreated. Clinical stage is according to AJCC and UICC's TNM system(2002). Hospital patients admitted in the same period with benign lung disease and excluded the existence of other primartumor were involved at random. The data were analyzed with SPSS13.O.Because the data is skewness distribution,the descriptive statistics used median;Chi-Square test,K-W test were used to analyze the data.Result1. The blood level of CEA,CA125,CYFRA21-1,SCC-Ag and TSGF in lung cancer patients were higher than those in benign lung disease patients respectively,had significant difference between them (P <0.05).2. The blood level and positive rates of CEA,CYFRA21-1,SCC-Ag and TSGF have no significant difference between squamous cell carcinoma and adenoeareinoma (P >0.05). The blood level of CA125 in adenoeareinoma was higher than the one in squamous cell careinoma with significant difference between them (P <0.05).The positive rates of CA125 has no significant difference between squamous cell carcinoma and adenoeareinoma (P >0.05).3.The positive rates of CEA,CA125,CYFRA21-1 and TSGF in stageâ…¢and stageâ…£patients were 56.3%,71.9%,50.0% and 65.6% respectively,much higher than those in stageâ… and stageâ…¡,there was significant difference between them (P <0.05).4. The sensitivity rates of combined detection of CEA,CA125,CYFRA21-1,SCC-Ag and TSGF were higher than detecting one of them,and the specificity rates were lower.The diagnostic index of squamous cell carcinoma maybe increased by combining test of CEA,CA125,CYFRA21-1,SCC-Ag and TSGF. In adenocarcinoma group , The Unit CEA + TSGF diagnostic index (162.2%) is the highest in the joint inspection of two, three and four tumor markers. There is no superiority in increasing the number of tumor markers to improve diagnosis index .Although the sensitivity of the combination the five tumor marker were the highest, the diagnostic index and Specificity were lower.Conclusion1. CEA,CA125,CYFRA21-1,SCC-Ag and TSGF are of some value for LC diagnosis. However, there is not grate value of single item detection in identification pathological type of lung cancer.2. CEA,CA125,CYFRA21-1 are advanced of clinical stage.3. The combined detection of CEA,CA125,CYFRA21-1,SCC-Ag and TSGF is a valuable method,which can raise Lung cancer's detection rate and the sensitivity.