A Primary Investigation Of The Effect Of Lycium Bararum Polysaccharides On Aging And Sub-health In Human

With the improved quality of life,the sub-health and aging issues begin to be concerned about,and the appearance of "sub-health state" indicates that the core issues of modern medicine research are shifting from the disease state to the disease control and prevention.At present, though hundreds of drugs are used to prevent sub-health and aging,the effectiveness is limited.However,various of polysaccharides may be the exception,and nowadays,more than 30 types of it has been widely applied in clinical.With the discovery of its new characteristics,more and more clinical applications will be framed.Combined with the free radical oxidation and non-enzymatic glycation,and based on the biochemical mechanism of the development of age pigment,Dr.Yin and Brunk proposed the carbonyl stress theory of aging.According to these theories,this study will explore the anti-oxidative stress and anti-carbonyl stress functions of Lycium Bararum Polysaccharides(LBP) from its effects on superoxide dismutase(SOD) and malondialdehyde(MDA),with the aim to discover its mechanism of anti-aging and anti-sub-health and providing data support for following clinical application.Results showed that there is a significant decrease in SOD activity and IL-2 content and increase in MDA content in old objects compared with young objects,and the sub-health group has lower SOD activity and higher MDA content compared with health group,but has no significant. After oral administration of Lycium Bararum Polysaccharides for long time,the SOD activity and IL-2 content increased significantly and the MDA content decreased significantly in both old group and sub-health group.These result indicate that the Lycium Bararum Polysaccharides could improve the aging and sub-health from its role of anti-oxidative stress and anti-carbonyl stress.