Treating Four Refractory And Relapse Acute Myelocytic Leukemia Patients With Sequential Dual Induction Chemotherapy: FA Combined With Priming Chemotherapy

Objective:To investigate the efficacy of FA combined with granulocyte colony-stimulating factor priming chemotherapy in refractory and relapse leukemia.Method:Sequential dual induction chemotherapy was used to treat 4 cases of refractory and relapse leukemia.Clinical manifestations,blood count,blood biochemical parameters, side effect and bone marrow smears were measured during the courses.Result:4 patients,3 male and 1 female,were enrolled.One M₁,two M₂,one M₄ were included.Age was from 17 to 39 years old.Of the 4 cases,3 got complete remission;1 died of serious infection without completing the chemotherapy course.In addition,the death had high fever before chemotherapy for over 10 days.So,wo just could abserved the three patients.Time to achieve CR was on the 13^th～20^th day from the end of the priming chemotherapy.Neutropenia began at the time of the 9^th～18^thdays after the priming regimen initiating and lasted 7～11 days.Hyphemia began at the 7^th～11^th days and lasted 9～12 days.Thrombocytopenia began at the 1^th～7^th days and lasted 13～15 days.Conclusion:FA and CAG sequential dual induction chemotherapy showed obvious efficacy for refractory and relapse leukemia and gain chance for hematopoietic stem cell transplantation.