| Objective To observe the effect of metallothionein(MT) lead-expelling tablets on blood lead levels,contents of trace elements Zn,Fe,Ca,Mg,Cu and Hb in lead poisoning children and the improvement of clinical syndrome.To study the mechanism and therapeutic effect of metallothionein on lean poisoning children.To provide evidence for the prevention of lead poisoning.Methods Two hundred and forty cases of lead poisoning children were divided into two groups randomly.MT lead-expelling tablets were given to the experiment group,placebo was given to control group.After oral administration of MT lead-expelling tablets or placebo for 1 and 2 months, blood lead levels,contents of elements Zn,Fe,Ca,Mg,Cu and Hb were determined.Evaluate the clinical syndromes before and after therapy.Results After 2 months treatment,the blood lead level(μg·L-1,65±16) in the experiment group were obviously lower than that(112±24)of in control group(P＜0.01),and the contents of blood zinc,iron(P＜0.01)and magnesium(P＜0.05) were increased,while contents of blood calcium and copper were not changed(P＞0.05).The level of Hb in experiment group increased much after therapy(P＜0.01).The improvement of clinical syndromes in the experiment group is priory to control group.The red blood and white blood count,the electrocardiograph,the function of liver and kidney all did not change much in experiment group of the a hundred and eighteen children(P＞0.05).Conclusion The improvement of clinical syndromes and HB of MT lead-expelling tablets in experimental group is priory to that of in control group without side effect.MT lead-expelling tablets can decrease the blood lead levels,maintain the balance of elements in lead poisoning children and increase Hb.It is an effective and safe medieine in the treatment of children with lead poisoning.
|
PDF Full Text Request