| Objective: To investigate the expressions of PDGF in serum and BA(basilar artery) vessel walls after SAH in Rats and to study the relationships with cerebral vasospasm (CVS).Methods: 55 health male Sprague-dawley(SD) rats were assigned randomly into following groups: Normal group, Control group(injected normal sodium through cisterna magna only). The expressions of PDGF in serum following SAH at different time point were detected by ELISA. Meanwhile, preserve the corresponding samples to examine the morphologic changes of BA depth and internal diameter. The expressions of PDGF in BA vessel walls were detected by immunohistochemistry method.Results: (1) Since 1st day after SAH, The serum PDGF level in rats was increased and it was higher than the normal and control groups on 3rd day ,5th day and 7th day,among which the highest level appeared on 3rd day. On 14 th day, it was normal as control groups. (2)After SAH, the concentration of PDGF increased on 1st day to 7th day , and it was higher than the normal and control groups at the same points. The highest level appeared on 3rd day. On 14 th day, it was normal as control groups. (3) After SAH, the expressions of PDGF in BA(basilar artery) vessel walls increased on 1st day to 7th day , and it was higher than the normal and control groups at the same points. The highest level appeared on 3rd day and 5th day. On 14 th day, it was normal as control groups.Conclusions: 1. The pathological changes including morphological changes, artery narrowing, thickness of arterial wall suggests that CVS happens after SAH. 2. The changings of the expression of PDGF in serum have coincidences with that of cerebral vasospasm. It was direct correlation. While the expressions of PDGF in BA vessel walls increasing , the cerebral vasospasm and the concentration of PDGF in serum enhance timely. It suggests that PDGF participate the pathological course of cerebral vasospasm.
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