| Objective:By investigating the association between ankle-brachial index(ABI) and various risk factors in hospitalized patients with lower extremity arteriosclerosis occlusive disease (LEASOD),to find out the risk factors those have prominent roles in promoting the development of the disease.To provide a certain basis for the research of the cause of LEASOD,and its primary,secondary prevention,as well as the clinically target-oriented treatment.Methods:The objects of present study were selected from patients with LEASOD,who were consecutively admitted to the division of general surgery in first affiliated hospital Shan Xi medical university from January 2005 to December 2008.After collecting their clinical information such as gender,age,height,weight,blood pressure,ABI value,blood lipid profile, fibrinogen(FIB),the history of hypertension,diabetes mellitus(DM),dyslipidemia,coronary heart disease,stroke and smoking and so on,we chose 106 patients whose data was complete. All subjects were divided into three groups based on ABI values,0.7≤ABI≤0.9 for mild LEASOD group,0.4≤ABI＜0.7 as moderate,ABI＜0.4 for severe.χ~2 Test or One-Way ANOVA were used to compare among the three groups the proportion of male and female,smoker,the prevalence rate of hypertension,DM,dyslipidemia,coronary heart disease and stroke,age,body mass index(BMI),blood pressure,the duration of hypertension,DM and smoking,serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C) and FIB.Multiple linear regression analysis was performed to evaluate the correlation between ABI and each of the above-mentioned risk factors.Results:1.There were no significant differences in BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),the highest SBP,the highest DBP,DM duration,TG,LDL-C,the prevalence rate of hypertension,dyslipidemia,coronary heart disease,stroke and the proportion of smoker among the three groups.2.The differences of ABI value,age,duration of hypertension and smoking,TC,HDL-C,FIB, the proportion of male and female,and the prevalence of DM were statistically significant among the three groups,these variables were given P values of＜0.001,0.001,0.009,0.028, 0.004,＜0.001,0.005,0.001 and 0.037,respectively.But,only the multiple comparisons of ABI value and the age among the three groups showed the differences of them were statistically significant(P＜0.001 and P＜0.05).3.Multiple linear regression results indicated that ABI correlated significantly with gender,age, hypertension,DM,HDL-C and the duration of smoking.Conclusion:1.The number of male was obviously more than female's in patients with LEASOD,and in whom,there was a high prevalence of smoking,hypertension,DM and dyslipidemia.2.ABI was generally used to evaluate the severity of LEASOD and extent of lower limb ischemia.The patients with lower ABI value(namely,the more serious condition),were often older.There was both a higher prevalence of hypertension,DM and dyslipidemia,and a longer history of hypertension,DM and smoking in those patients.And,of those patients,the blood pressure measurements,laboratory test results such as TC,TG,LDL-C and FIB were higher.But, HDL-C was lower.3.Decrease of the concentration of HDL-C,hypertension,DM,long-term smoking,and increase of the age were the major factors aggravating LEASOD.HDL-C has a protective effect on LEASOD.And this protective effect is probably more significant than the role of LDL-C as a risk factor.
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