Operative Stress Response And Visceral Proteins After Laparoscopic-assisted Resection Of Colorectal Carcinoma For Advanced Age Patient

Objective To compare the alterations of operative stress response-reactive protein (CRP),interleukin-6(IL-6),IL-10 and visceral proteins after laparoscopic-assisted and open resection of colorectal carcinoma in advanced age patients.Methods According to the patients' choice of the operation,laparoscopic-assisted (n=20) and open(n=21) resection of colorectal carcinoma were performed.IL-6,IL-10,CRP and visceral protein which includes Albumin(ALB),Prealbumin(PRE), Transferrin(TRF) and Retinal-binding protein(RBP) were assayed preoperatively and at the 6h,1st,2nd and 3rd day postoperatively.Results groups were comparable for patient characteristics,such as sex,boky mass index and age.Compared with the preoperative period,the CRP levels in both groups were increased significantly on the 1st,2nd and 3rd day(P<0.001) and peaked on the 2nd day postoperatively.The responses in the laparoscopic group was significantly less than those in the open group(P<0.01).The plasma levels of IL-6 and IL-10 were significantly increased after the operation in both groups,which was significantly lower in the laparoscopic group.The levels of ALB,PRE,TRF and RbP significantly decreased after operation in both groups(P<0.01),but there were no differences at the 1st and 2nd day(P>0.05),all the levels of the four proteins in the laparoscopic group were significantly higher than those in the open group at the 3rd day postoperatively(P<0.01).Conclusions Laparoscopic-assisted resection of colorectal carcinoma gives lower levels of stress responses compared with open surgery for advanced age patient,which benefits the restoration of energy metabolism and visceral proteins.It's a strong support for the practice of minimal invasive surgery.