Impact Of Patients Over 75 Years Of Age Laparoscope Colorectal Cancer Radical Operation For Body Stress And Visceral Protein

Objective To compare the alterations of operative stress response-reactive interleukin-6 (IL-6),IL-10 and visceral proteins after laparoscopic-assisted and open resection of colorectal carcinoma in patients over 75 years of ageMethods According to patients'choice of operation, ether laparoscopic-assisted (n =20, Laparoscopic Group) or open (n=20, Open Group) resection of rectal carcinoma was performed. were performed. IL-6,IL-10 and visceral protein which includes Prealbumin(PRE), Transferrin(TRF) and Retinal-binding protein(RBP) were assayed preoperatively and at the 1st,2nd and 3rd day postoperatively.Results Compared to the preoperative period, The plasma levels of IL-6 and IL-10 were significantly increased after the operation was significantly lower in the laparoscopic group. The levels of PRE, TRF and RbP were significantly decreased after operation in both groups (P<0.01). But there was no significant difference between the two groups in levels of PRE, TRF and RbP on the frist and 2nd postoperative day (P>0.05). and the levels of the 3 proteins in the Laparoscopic Group were significantly higher than those in the Open Group on the 3rd postoperative day (P<0.01).Conclusions Laparosoopic-assisted resection of colorectal carcinoma results in less prominent stress response compared to open surgery in patients over 75 years of age, These benefit the restoration of visceral proteins. It's a strong support for the practice of minimal invasive surgery. However, both the laparoscopic and open operation can result in significant decrease in visceral proteins at early period postoperatively.