The Influence Of Fufangfeiji Decoction To Lewis Lung Cancer Mouse's VEGF Protein Expression

Objective:To study the effect of Fufanfeiji Decoction(FJD) on Lewis transp-lantation tumor and metastatic tumor and its combinative effect with DDP.Method:All C57BL/6 mice(n=25) were randomly divided into five groups as follows:the blank group,the control group,DDP group (intraperitoneal injection of DDP in dose of 3mg/(kg·2d)),FJD group (with FJD in dose of 21g/(kg·d) orally) and group with medium two dose FJD and DDP(FJD+DDP group),each n=25.The effect of FJD and FJD+DDP on Lewis transp-lantation tumor,metastatic tumor,and the expression of VEGF,and combinative effect of FJD with DDP were observed.Result:1.The inhibitory rate(IR) in FJP group was 36.22%,and the weight of tumor was(1.252±0.067) g,which was lower than that in the control group (1.963±0.178)g,P＜0.05.2.The inhibitory rate in FJD+DDP group was(71.12%) significant difference compared with that in DDP group(51.91%) and the combinative effect was 0.85＜q＜1.15 which showed an additive effect.The inhibitory cancer metastasis rate was 55.12%in FJD+DDP with an significant difference compared with 38.54%in DDP group.The metastases were less in FJD+DDP group(0.92±0.50) g than those in the DDP group(1.26±0.81) g,P＜0.05.3.FJD+DDP can effect the expression of VEGF,P＜0.05.The expression of VEGF in FJD+DDP group was lower than that in DDP group,P＜0.05.Conclusion:1.FJD has an inhibittory effect on Lewis transp-lantation tumor and metastatic tumor. 2.The combination of FJD and DDP shows an additive effect and obvious inhibitory effect on Lewis transp-lantation tumor and metastatic tumor.3.FJD+DDP can remarkably inhibit the expression of VEGF.