| Piper wallichii(Miq.) Hand.-Mazz.,belonging to the Piperaceae family,is a perennial plant that is widely distributed in Sichuang,Hunan,and Yunnan Province in China.The aerial part of this plant is used as an effective folk medicine in China to treat beriberoid disease,alleviate pain,dredge meridian passage,and improve sexual function.Modern pharmacology research has elucidated the constituents of this plant have significant anti-platelet-activating factor(PAF) activity.We find that the CH2Cl2 extract of Piper wallichii(Miq.) Hand.-Mazz.has neurotrophic activity for PC12 cell.Phytochemical investigation led to the isolation of eighteen compounds.On the basis of their characteristics and spectra,the structures of these compounds were established,including twelve neolignans:isohancinone C(1), isofutoquinol A(2),(+)-denudatin B(3),(+)-kadsurenone(4),(+)-burchellin(5),7S, 8S,1'R-Δ8'-3,4,5'-trimethoxy-1',4'-dihydro-4'-oxo-7.O.2'.8.1'-neolignan(6),(+)-licarinA(7),eupomatenoid-7(8),wallichinine(9),hancinone B(10),hancinone C(11),hancinone D(12);five amides:N-isobutyl-deca-trans-2-trans-4-dienamide(13),dihydropiperlonguminine(14),piperlonguminine(15),futoamide(16),retrofractamide A(17);and one lignan:galgravin(18).Compound 1,named isohancinone C,is a new neolignan and never found before.Compound 2,5,6,7,8,10,12,16 and 17 were isolated from this plant for the first time.Compound 13,14,15,16 and 17 have been shown neurotrophic activity for PC12 cell. |
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