The Influence Of Intratumoral Injection Of Pinyangmycin On The Expression Levels Of VEGF,bFGF And PCNA In The Proliferating Hemangioma's Tissue

Objective To explore the influence of intratumoral injection of pinyangmycin on the expression levels of VEGF,PCNA and bFGF in proliferating hemangioma. methods One hundred and forty patients with proliferating hemangioma were randomly divided into seven groups, twenty patients every group .Group A as control group. Group B were injected with Pinyangmycin(1mg|ml) before 1 week .Group C were injected with pinyangmycin and dexamethasonum before one week. Group D were injected with Pinyangmycin before two weeks. Group E were injected with pinyangmycin and dexamethasonum before two weeks. Group F were injected with Pinyangmycin before three weeks. Group G were injected with pinyangmycin and dexamethasonum before three weeks. Observe the tissue configuration of above examples by histochemistry method and detect the expression level of the VEGF,bFGF and PCNA by immunohistochemistry method. Results The expressions of VEGF in the A,F,G groups were 78.00±3.57,75.90±2.63,70.54±3.11 and in the B,C,D,E groups were 56.35±2.60,41.50±2.12,40.10±2.27,27.70±1.40.The variance was significance(P<0.05). The expressions of bFGF in the A,B,F,G groups were 81.40±2.00,73.55±1.67, 71.45±3.88,69.70±3.76 and in the C,D,E groups were 53.65±2.29,45.35±1.82,31.90±2.55, The variance was significance(P<0.05). The expressions of PCNA in the A,F,G groups were 79.55±3.15, 76.30±3.71,69.20±2.97 and in the B,C,D,E groups were 57.30±2.34,44.95±2.47,44.25±1.60,34.00±2.25 The variance was significance(P<0.05). Conclusion Intratumoral injection of pinyangmycin in proliferating hemangioma may obviously restrain the expressions of VEGF and bFGF to inhibit it proliferation. Dexamethasonum and Pinyangmycin enhance role of each other . intratumoral injection of Pinyangmycin and Dexamethasonum before operating will shrink area of hemangioma.decrease demage of operation to body.