Advanced Glycation Index And Atherosclerosis In Newly Diagnosed Type 2 Diabetes

Objective: To study the relationship between advanced glycation index and the formation of atherosclerosis in recently diagnosed type 2 diabetes mellitus.Methods: One hundred and five patients with type 2 diabetes from the "National Eleventh Five-Year" plan "Macrovascular complications prevention: experimental and control model in newly diagnosed type 2 diabetes" under taken in center of The Second Affiliated Hospital of Dalian Medical University. The data includes the age, sex, history of smoking, history of high blood pressure etc were collected. Fasting plasma glucose (FPG), serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glycosylated hemoglobin (HbA1c), serum creatinine (Cr), blood urea nitrogen (BUN) of the patients were measured at the time of enrollment and one year later while ultrasound measurement of the intina-thickness, numbers, size, and echo characteristics of plaque of common carotid artery, femoral artery, iliac artery were taken by a trained doctor. At the end of the first year, blood were withdrawn and the sera were then diluted into five different concentrations with 0.02mmol/L phosphate saline, fluorescence was read by a spectrophotometer with excitation wavelength of 370 nm and measurement wave length of 440 nm, and slit width of 4 nm in the Central Laboratory of Dalian Medical University. Linear regression was estimated, the slop of the linear function was used as the advanced glycation index (AGI) .Results: AGI was positively related to the baseline carotid intima-media thickness (C-IMT) as in high AGI group the C-IMT was 1.45±0.36 mm, in median AGI group, 1.28±0.33 mm and in low AGI group, 1.16±0.22 mm (P<0.05); No significant difference was found among the three sets of one year follow-up of the C-IMT. AGI was also associated with Cr levels (F=3.192, 4.964, P<0.05) and TG. No association was found relating to smoking, age, duration of diabetes, hypertension, baseline and on year follow-up femoral artery intima-media thickness(F-IMT), iliac artery intima-media thickness(I-IMT), HbA1c, FPG, TC, TG, LDL-C, HDL-C. Regression analysis also showed that AGI is positively correlated with baseline C-IMT (r=0.26, P<0.05), with Cr both at baseline and one year follow-up (r=0.24, 0.39, P<0.05).Conclusion: The Cr level inflences AGI level in the patients with type 2 diabetes whose renal function is within normal range. AGI correlate with baseline C-IMT of patients with type 2 diabetes, not with one year follow-up. Longer time of intervetnion is needed to observe any relation with change of C-IMT.