The Exrression Of Andgrogen Receptor, Thrombospondin-1 In Nonmalignant And Malignant Prostate Tissue And The Relationship Between Androgen Receptor, Thrombospondin-1 And Angiogenesis In Nonmalignant And Malignant Prostate Tissue

Objective: To investigate the expression of androgen receptor (AR) and thrombospondin-1 (TSP-1) in human benign prostatic hyperplasia (BPH)and prostate cancer(Pca), and to explore the relationship between them and angiogenesis.Methods:eighty specimens from BPH(20) and Pca(60) were comprised in the study.The Pca was divided into low Gleason score group (Gleason score<7) and high Gleason score group (Gleason score≥7),and into non-bone metastasis group and bone metastasis group. The expression of AR, TSP-1 and microvesel density (MVD) were detected by immunohisto-chemistry (two-step method) .Results: The positive rates of AR and TSP-1 in BPH group were significantly higher than those in Pca group, the MVD mounts in BPH group was significantly lower than that in Pca group; The positive rates of AR and TSP-1 in lower Gleason score group were significantly higher than those in higher Gleason score group, the MVD mounts in lower Gleason score group was significantly lower than that in higher Gleason score group; The positive rates of AR and TSP-1 in non-bone metastasis group were significantly higher than those in bone metastasis group, the MVD mounts in non-bone metastasis group was significantly lower than that in bone metastasis group.MVD mounts in AR positive and TSP-1 positive group were significantly lower than those in AR negative and TSP-1negative group(all P<0.01). There was positive correlation between the expression of AR and TSP-1(r=0.722,P<0.05).Conclusion: Low expressions of AR and TSP-1in Pca have close relations with tumor Gleason score and condition of bone metastasis . mutation of AR might repress TSP-1,which might promot angiogenesis in prostate cancer.