Study Of Expressions And Correlations Of VCL,PPA1,AR In Prostate Carcinoma

Objective:To study the expression of three factors,Vinculin(VCL), androgen Receptor(AR),and inorganic pyrophosphatase(PPA1) in benign prostatic hyperplasia(BPH),and prostate cancer(PCa);To clear and analyze the mutual relationship between the three factors and prostate cancer's different clinical stages,histological grade,and PSA level;To provide a theory for the occurrence and the development of PCa.Methods:To detected the expression of VCL,AR,and PPA1 in 18 cases of BPH tissue and 38 cases of PCa tissue by immunohistochemistry; To analysis the differences of VCL,AR,PPA1 in the expression of BPH and PCa;To detected the expression of VCL,AR,and PPA1 in prostate cancer's different clinical stages,histological grade,and PSA level;To analysis the correlation of VCL,AR,and PPA1.Results:1) The positive expression rate of VCL,AR,PPA1 were 28%,56%,22%in BPH tissues,58%,53%,39%in PCa tissues.The positive rate of VCL in PCa was more than in BPH tissues(P＜0.05),the positive rate of AR and PPA1 were no significant difference in BPH and PCa(P＞0.05).2) There was a close relationship between the expression of VCL, AR and tumor clinical stage,pathological grade in PCa tissue(P＜0.05), but without significant relationship in the value of PSA(P＞0.05).The expression of PPA1 was not significant correlation with the tumor clinical stage,pathological grade and the value of PSA(P＞0.05).3) There was a positive correlation between the expression of VCL and the expression of AR in PCa tissue(r= 0.489,P= 0.002＜0.05).There was no correlation in the expression of PPA1,VCL,and AR in PCa tissue (P＞0.05).Conclusions:1) The differences between the expressions of VCL in BPH and PCa predicted VCL could be used as an indicator for the differential diagnosis of benign and malignant prostate disease;2) The expression of AR and VCL reduced gradually with the progression of PCa and there was a positive correlation between them. The combination of the two indicators could be an indicator of diagnosis and prognosis to evaluate the development of PCa;3) PPA1 wasn't an effective indicator to evaluate the progression of PCa.