Study Of IL-10,hsCRP Levels And Significance In Maternal Serum, Umbilical Cord Serum

Objective:To investigate the change of materal serum interleukin-10 (IL-10) and high sensitive c-reactive protein(hsCRP) in term premature rupture membrance and preterm premature rupture membrance.Methods:Serum levels IL-10 and hsCRP were measured by enzyme-linked immunosorbent assay.60 cases were recuited in study group,including 30 cases term premature rupture membrance and 30 cases preterm premature rupture membrance;30 cases in control group with normal pregnancy women.Result:the levels of serum IL-10 of term premature rupture membrances with subclinical choriiamnionitis were lower than that of term premature rupture membrances without subclinical choriiamnionitis (t=3.029,P=0.005,);that of normal pregnancy women(t=7.27,P=0.00),the levels of serum and umbilical of IL-10 of preterm premature rupture membrances with wsubclinical choriiamnionitis were lower than that of preterm premature rupture membrances with subclinical choriiamnionitis(t=-3.726,P=0.001),the levels of serum IL-10 in preterm premature rupture with subclinical chorioamnionitis were significantly lower than that of preterm premature rupture membrances without subclinical chorioamnionitis(t=2.932,P=0.00),tthe levels of serum IL-10in preterm premature rupture with subclinical chorioamnionitis were significantly higher than that of normal pregnancy women(t=5.505,P=0.00).the levels of serum hsCRP in term premature rupture with subclinical chorioamnionitis were significantly higher than that of term premature rupture without subclinical chorioamnionitis(t=3.118,P=0.000) the levels of serum hsCRP in preterm premature rupture with subclinical chorioamnionitis were higher than that of in preterm premature without subclinical chorioamnionitis (t=8.535,P=0.00),the levels of serum hsCRP in preterm premature were significantly higher than that of term premature rupture membrances,(t=6.704,P=0.00),the levels of serum hsCRP in term premature rupture with subclinical chorioamnionitis were significantly higher than that of normal pregnancy women(t=4.126,P=0.00),the levels of serum hsCRP in preterm premature rupture with subclinical chorioamnionitis were significantly higher than that of normal pregnancy women(t=11.405,P=0.00).The morbidity rate in the infectional group is higher than the control group,(P＜0.05)Conclusion:1.the levels of serum IL-10 in women with subclinical choriiamnionitis of term premature rupture membrances were significantly lower than normal pregnancy women and term premature rupture membrances without subclinical choriiamnionitis,the levels of serum IL-10in women with subclinica choriiamnionitis of preterm premature rupture membrances were significantly lower than preterm premature rupture membrances without subclinical chorioamnionitis, maybe,IL-10 be an anti-inflammation.2.hsCRP in pregnancywere high in term and preterm premature rupture membrances with subclinical choroamnionitis but it were low in term and preterm premature rupture membrances without subclinical chorioamnionitis and it be a sensitive indicator in diagnosising subclinical chorioamnionitis.