The Cross-talk Effect Of HsCRP And Other Cardiovascular Risks On The Coronary Atherosclerosis

Background:Hypertension, Diabetes, dislipidemia and fat are traditional risk factors of coronary artery disease. And they are also the components of metabolic syndrome. But not every patient with one or more of these risk factors will develop to CAD. High sensitivity C-reactive Protein (hsCRP) is an important marker of inflammation and a predictor for cardiovascular disease. It plays an important role in the development of plaque. There are little reports about the cross-talk effect of hsCRP and other cardiovascular risks on the coronary atherosclerosis.Objective:To investigate the cross-talk effect of hsCRP and other cardiovascular risks on the coronary atherosclerosis.Method:To measure the level of hsCRP and other biomarkers in 253 patients with angina, and record their SBP, DBP, height, weight and smoking history. All patients were performed coronary angiograph, and the Gensini Score was used to evaluate the severity of coronary atherosclerosis. Data analysis was employed by SPSS 15.0. All P value were two-tailed and P<0. 05 was deemed statistically significant.Results:(1) The LoghsCRP level was significantly higher in CAD group than control group.(2) The LogGensini level was significantly lower in the group with the lower hsCRP level than those with medium or higher hsCRP level.(3) HsCRP is significantly positively correlated with elder, hypertension, diabetes, dislipidemia, the number of metabolic syndrome components and metabolic syndrome. However hsCRP is significantly negatively correlated with HDL. But there seemed no correlation among hsCRP, gender and fat.(4) HsCRP is an independent predictor of CAD. And compared with lower hsCRP group(with hsCRP level equal or less than 0.71mg/L), the higher hsCRP group( with hsCRP level more than 0.71 mg/L) will have higher CAD risk (OR=2.239, P<0.05).(5) After combined with hsCRP, the correlations between LogGensini and BMI,SBP,DBP,FBG,BG2h,HDL and LDL increased. No matter what the gender was, the combination of hsCRP with FBG,LDL and HbAlc always showed significant correlations with LogGensini.(6) HsCRP is correlated with metabolic syndrome, and the LoghsCRP level increased with the increasement of the number of metabolic syndrome components. Those with metabolic syndrome had a significantly higher LoghsCRP level than those without. And compared with the lower hsCRP level group, the OR for metabolic syndrome in the upper two hsCRP level groups are 2.982 and 4.230 respectively (P< 0.01) .(7) Compared with those without metabolic syndrome and hsCRP level equal or less than 0.71mg/L, the OR for CAD in those with metabolic syndrome and hsCRP level more than 0.71mg/L was 2.179 (P<0.05).Conclusions:(1) HsCRP was significantly correlated with the severity of coronary artery atherosclerosis.(2) After combined with hsCRP, the correlations between LogGensini and BMI,SBP,DBP,FBG,BG2h,HDL and LDL increased.(3) HsCRP was significantly correlated with metabolic syndrome.(4) HsCRP provided metabolic syndrome an added value of predicting CAD.