| Objectives To detect the levels of serum interleukin-10 (IL-10) and high sensitive C reactive protein(hs-CRP) in military old men with metabolic syndrome(MS), and to explore the relationship among the inflammatory biomarker IL-10, hs-CRP and MS.Methods An investigation were carried out among totally four hundred and eight military senile male subjects in Hunan province who were enrolled in 163 Hospital from November to December of 2006. Waist circumference(WC), weight, height, blood pressure, fasting plasma glucose(FPG) and lipid-profile were measured. Body mass index(BMI) was calculated. Characteristics of metabolic disorders were analyzed. Fifty-eight patients with MS and twenty-nine age-matched control subjects were enrolled in this study based on the diagnostic criteria suggested by Intemational Diabetes Federation (IDF). Blood pressure, waist circumference, weight, height, body mass index(BMI), lipid-profile, fasting plasma glucose(FPG), fasting plasma insulin (FINS), homeostasis model assessment of Insulin Resistance (HOMA- IR)were measured. The concentration of serum IL-10 was measured by enzyme linked immunosorbent assay(ELISA), and serum hs-CRP level by enhanced immunoturbidimetric assay.Results 1. Among totally four hundred and eight military senile male subjects, the number of subjects with obesity or overweight accounted for two hundred and thirty seven cases(58.1%). The number of subjects with central obesity(waist circumference≥90cm), hypertension, high plasma glucose and lipid disorders (hypertriglyceridemia or/and low LDL cholesterol) were two hundred and forty three cases (51.6%), two hundred and eighty seven cases(70.3%), one hundred and thirty five cases(33.1%)and ninety five cases(23.3%) respectively. And the number of patients with MS was one hundred and thirty five(33.1%). The patients with over three MS associated disorders were nearly 30% in the whole senile group. 2. Serum IL-10 level in MS group was significantly lower than that in control group (P<0.05). The subjects were subgrouped according to the levels of HOMA-IR, it was shown that the concentration of IL-10 in the insulin resistance(IR) subgroup (HOMA-IR≥4.31)was significantly lower than that in the non-IR subgroup(HOMA-IR<4.31) (P=0.000). 3. The concentration of hs-CRP in patients with MS was obviously higher than that in the controls (P<0.05). The subjects were subgrouped according to the levels of HOMA-IR or WC, it is shown that the concentration of hs-CRP in non-insulin resistance(IR) subgroup (HOMA-IR<4.31) was lower than that in the IR subgroup (HOMA-IR≥4.31) (P>0.05); and serum hs-CRP level in the central obesity subgroup (WC≥90cm) was higher than that in the non-central obesity subgroup (WC<90cm) (P=0.008). The level of serum hs-CRP increased as the number of MS components was increasing, in these patients with MS. 4. Using Pearson's correlation analysis, in the MS group, serum IL-10 levels showed a positive correlation with HOMA-IR (r=-0.797, P=0.000), FINS (r=-0.731, P=0.000) and FPG(r=-0.303, P=0.021), and hs-CRP showed a positive correlation with age(r=0.270, P=0.040) and BMI(r=0.346, P=0.008). 5. Stepwise regression analysis showed that in patients with MS, waist circumference, HOMA-IR and FINS might be the influencing factors of IL-10; age and BMI might be the influencing factors of hs-CRP in these patients.Conclusions 1. Among totally four hundred and eight military senile male subjects who were retired, the proportion of the patients who suffered from diseases associated with MS was high. 2. In eldly male patients with MS, the concentration of serum IL-10 decreased, and serum hs-CRP level increased obviously. This suggested that there was chronic inflammatory state existed. 3. In eldly male patients with MS, the level of IL-10 decreased which might be closely related with hyperinsulin and insulin resistance. 4. The level of serum hs-CRP, which might be associated with age and BMI, elevated as the increasing numbers of MS component, in these old male patients with MS.
|
PDF Full Text Request